HomeHealth articlesacneAcne Fulminans | Causes | Risk | Diagnosis | Treatment

Acne Fulminans - Causes, Risk, Diagnosis, and Treatment

Verified dataVerified data

4 min read


Acne fulminans are one of the most severe forms of acne.

Medically reviewed by

Dr. Dhepe Snehal Madhav

Published At March 16, 2022
Reviewed AtJanuary 3, 2024

What Are Acne Fulminans?

Acne fulminans, a severe skin disorder, is one of the worst forms of acne, accompanied by systemic symptoms. It is also known as acne maligna. It usually causes sudden onset ulceration and bleeding with pain. It also causes severe scarring. In addition to systemic symptoms like fever and polyarthritis (joint pain in more than five joints), it also causes bone lesions and abnormal bodily parameters. Acne fulminans do not respond to regular antibacterial therapy for acne but can be well managed through debridement and oral steroids.

What Causes Acne Fulminans?

  • Though the exact cause of acne fulminans is not understood, the following conditions are being found to be the causative factors;

  • In people with severe acne complaints, the use of high doses of Isotretinoin is linked to triggering acne fulminans.

  • High levels of testosterone and the use of anabolic steroids can increase sebum secretion and also cause an increase in the population density of cutibacterium acnes (formerly propionibacterium acnes) in the skin. The antigens of these bacteria trigger an immunologic reaction in the body to cause acne fulminans.

  • Genetic inheritance.

  • Autoimmunity is also regarded as a cause of circulating immune complexes in some patients with acne fulminans.

What Syndromes Are Linked to Acne Fulminans?

  • Acne fulminans can also be one of the parts of the following syndromes;

  • Osteitis syndrome, hyperostosis, pustulosis, synovitis, and acne are collectively known as SAPHO.

  • PAPA stands for pyogenic arthritis, pyoderma gangrenosum, and acne syndrome.

  • Pyoderma gangrenosum, acne, and hidradenitis suppurativa syndrome (PASH).

  • Pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa syndrome (PAPASH).

Is Acne Fulminans a Common Condition?

No. Acne fulminans is an uncommon condition, approximately only 150 cases have been discovered worldwide so far.

Who Is at Risk of Acne Fulminans?

It predominantly affects the adolescent male population of the white race aged between 13 and 22 years with a history of acne. These teen boys suddenly develop a large number of pimples on their back and around the chest region.

People with measles infection, late-onset congenital adrenal hyperplasia, and those taking anabolic steroids for bodybuilding are at increased risk, as the incidence of acne fulminans in such people has been previously reported.

What Are the Characteristic Features of Acne Fulminans?

  • The acne is usually of sudden onset and large in number.

  • The acne is painful, ulcerated, crusted, and hemorrhagic.

  • Numerous inflammatory nodules are found on the trunk.

  • Severe acne scarring.

  • Inflamed lesions appear cystic.

  • Fever.

  • Malaise.

  • Loss of appetite and weight.

  • Pain in multiple joints (polyarthritis, especially of the hip, thighs, and knee joints).

  • Erythema nodosum.

  • Splenomegaly.

  • Stooped posture.

  • Failure to respond to usual antibiotic therapy for acne.

  • Bone pain.

  • Osteolytic changes in the bone.

  • Though the characteristic feature of this condition is skin lesions, it is considered a systemic disease due to the involvement of several organs. Also, the affected people find it difficult and painful to walk due to arthralgia.

What Other Conditions Resemble Acne Fulminans?

Other conditions with similar characteristic features of acne fulminans include,

  • Acne conglobata.

  • Acne vulgaris.

  • Acneiform eruptions.

  • Pyoderma gangrenosum.

Which Is More Contagious: Boils or Acne?

  • Acne itself is not contagious. It is a skin condition caused by excess oil production, bacteria, and inflammation. It is not spread from person to person through contact.

  • Pimples, which are a symptom of acne, are also not contagious. They develop when cell debris and oil block the roots of hair, causing discomfort.

  • Boils, on the other hand, can be contagious. They are usually caused by a bacterial infection of the underlying hair and scalp follicles.

  • The bacteria-causing boils can spread through contact with the pus from the boil, especially if proper hygiene isn't maintained.

  • So, between boils and acne, boils have the potential to be more contagious due to the bacteria involved and their spread through contact with infected materials.

What Investigations Help Diagnose Acne Fulminans?

After visually examining your lesions, your physician will order the following investigations to reach a diagnosis.

  1. Complete blood count.

  2. Erythrocyte sedimentation rate.

  3. C-reactive protein.

  4. Liver function test.

  5. X-rays.

The following investigatory findings led to the diagnosis:

  1. Increased white blood cell count (leukocytosis).

  2. Anemia (low hemoglobin).

  3. Elevated erythrocyte sedimentation rate.

  4. Elevated C-reactive protein levels.

  5. Osteolytic lesions of the bone.

How Can Acne Fulminans Be Treated?

The following treatment methods are found beneficial in treating acne fulminans:

Combination of Oral Steroids and Isotretinoin - Oral steroids like Prednisone, 0.5 to 1 mg/kg/day, will be prescribed for at least two weeks if only cutaneous lesions are present and for four weeks if systemic symptoms accompany them. The dose will be gradually tapered off. Meanwhile, isotretinoin 0.1 mg/kg/day will also be prescribed for four weeks. It is started with a low dose, eventually increased until desired effects are achieved, and then decreased towards the end of the treatment. The minimum dose of isotretinoin should not exceed 120 mg/kg (and 150 mg/kg in case of relapse).

Oral steroids with supplemental intralesional therapy are also preferred. A combination of Prednisone and Dapsone (50 to 100 mg/day) or Cyclosporine is also effective. Though antibiotics do not yield good results, broad-spectrum systemic antibiotics like 300 mg Clindamycin thrice daily and 750 mg Levofloxacin daily in addition to 1 mg/kg/day oral Prednisolone are found beneficial in some people. However, oral isotretinoin and steroids are always superior to an antibiotic-isotretinoin combination in treating acne fulminans.

Pulsed dye laser therapy is also beneficial but does not improve the pain. In acne fulminans patients with ulcerative colitis, Diaminodiphenyl Sulfone is beneficial. If unresponsive to the above treatment options, Infliximab (monoclonal antibody against tumor necrosis factor-alpha) is used.

Note - Women undergoing treatment with isotretinoin should avoid getting pregnant within a month of discontinuing isotretinoin.

What Is the Prognosis of Acne Fulminans?

The condition gets managed better with treatment. Though the lesions subside, the scars persist. The recurrence is very rare. Bone lesions also resolve, but the radiologic findings remain unchanged after successful treatment.


As acne fulminans more profoundly affects the adolescent population, these adolescents eventually develop low self-esteem towards their appearance, as it greatly causes scarring, ulcerations, and crusts that seem unappealing. Suicidal ideation is also prevalent among the affected individuals due to unpleasant bodily lesions. This needs to be addressed, and prompt treatment should be sought.

Frequently Asked Questions


What Are the Triggering Factors of Acne Fulminans?

Acne fulminans is characterized by painful and ulcerated acne, mainly on the body's trunk. The main causative factor remains unknown. However, it gets triggered by high doses of Isotretinoin, which is used initially to treat acne. In addition, high doses of testosterone and anabolic steroids also activate the immune system by increasing sebum (oil) secretion and Propionibacterium acnes to cause acne fulminans.


Do Acne Fulminans Last Long?

Acne fulminans, also known as acne maligna, is a severe form of acne and causes systemic symptoms like fever, joint pain, and bone lesions. It lasts for several weeks but responds well to treatment with oral steroids, antibiotics, and intralesional therapy. The scars may remain even after the acne resolves, and its recurrence is rare.


Why Do I Get Acne Nodules?

Acne nodules are formed if the dead cells and bacteria Propionibacterium acnes get clogged within the pores by excess sebum (oil). It infects the deep layers of the skin, and a hard nodule is formed. The nodular acne is red, and the surrounding areas get inflamed and painful to touch.


Is Acne Fulminans Caused by Isotretinoin?

Isotretinoin, along with oral steroids, is used to treat acne fulminans. The dose of Isotretinoin is gradually increased to cure acne, and it is decreased at the end. However, the acne worsens when the dose increases, leading to Isotretinoin-induced acne fulminans without any systemic symptoms. It occurs during the first few weeks of treatment and resolves independently.


Are Acne Fulminans Common?

Acne fulminans is an uncommon but severe form of skin disorder. Only 150 cases of acne fulminans have been tracked down till now. It most commonly affects adolescent males 13 to 22 years of age. The acne occurs suddenly on the chest and back and is ulcerated. It is also found to occur in individuals with measles infection and intake of anabolic steroids.


Can Acne Be Treated With Methylprednisolone?

The suggested treatment of acne fulminans is oral steroids and Isotretinoin. The steroids like Methylprednisolone reduce the redness and swelling around the acne. The dose of steroids is gradually lowered within weeks to avoid various systemic complications of steroids.


What Is the Treatment for Acne Fulminans?

The acne fulminans is managed by the following medication:
- Oral corticosteroids like Prednisone are given.
A combination of oral steroids and Isotretinoin is found to be helpful in reducing the symptoms, and their dose is gradually decreased at the end of treatment.
- Oral antibiotics are suggested in case of secondary infections.
- Infliximab, a tumor necrosis factor-alpha (TNF alpha), is suggested if the acne does not resolve to other medications.


What Denotes That I Have Acne Conglobata?

Acne conglobata is also a severe form of skin disorder like acne fulminans. It is more common in men and produces painful nodules on the shoulder, chest, buttocks, thigh, and face. The nodules contain foul-smelling pus that breakdowns and fuses together. The areas around the nodules are highly inflamed.


How to Know if I Have Fungal Acne?

Fungal acne is caused by infection of the hair follicles in the skin. It occurs due to overgrowth of the yeast in the skin, medications, trapped moisture, and suppressed immunity. The disorder causes pus-filled nodules on the arms, chest, and back and causes itching. It is also referred to as pityrosporum folliculitis.


Does Acne Fulminans Affect Females?

Acne fulminans cause severe pain, ulcerated and hemorrhagic nodules. It is associated with an increased dose of Isotretinoin and anabolic steroids that increase the oil and population of Propionibacterium acnes on the skin. The disorder is more common in adolescent males and may rarely affect females.


What Are the Features of Acne Fulminans?

Acne fulminans cause sudden and more nodules in the skin. It is characterized by:
- Painful and crusted nodules.
- Ulcerated, inflammatory nodules mainly on the trunk.
- Acne scars are formed severely.
- It also causes fever, joint pain, loss of weight, stooped posture, enlarged liver and spleen.
Source Article IclonSourcesSource Article Arrow
Dr. Dhepe Snehal Madhav
Dr. Dhepe Snehal Madhav



Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Source Article ArrowMost popular articles

Do you have a question on


Ask a doctor online

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy