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Skin Graft Healing and Aftercare

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Skin graft healing and aftercare are critical components of recovery after a skin graft surgery. Read below to learn more about skin graft aftercare.

Written by

Dr. Sameeha M S

Medically reviewed by

Dr. Dhepe Snehal Madhav

Published At May 14, 2024
Reviewed AtMay 15, 2024


Healthy skin is utilized as a skin graft to replace missing or damaged skin. The transplant is usually obtained from another region of the body (donor location). Both the donor and graft sites must be treated as directed for optimal healing. The graft will take anywhere from two to four weeks or longer to cure. This varies between individuals and may be affected by the size of the graft.

What Is a Skin Graft?

A skin graft involves taking healthy skin from one part of the body and transplanting it to another. A skin graft will be performed by an experienced doctor to replace skin that has been severely injured. The inner thigh, buttocks, area beneath the collarbone, area in front of as well as behind the ear, upper arm, and the area below the collarbone are the source sites most frequently used for skin grafts. Skin grafts come in a variety of types, each with its own set of characteristics and indications:

  • Full-Thickness Skin Grafts: In this, the complete thickness of the skin, consisting of the outer layer (epidermis) and the underlying layer (dermis), is removed from the donor site. Later, it is transferred to the recipient site. These grafts usually produce better cosmetic and functional outcomes.

  • Split-Thickness Skin Grafts: In this only a piece of the donor site's dermis and epidermis are harvested. These grafts are widely utilized for significant burns and wounds because they may cover bigger areas. They have a better probability of survival, although they may not seem as natural as full-thickness grafts.

  • Composite Grafts: In comparison to split- or full-thickness skin grafts, composite grafts are frequently used to a diameter of 0.39 inches. Composite grafts are used in situations where the donor site lacks muscle or bone. The most frequent composite graft is made of cartilage and is used to strengthen the nose or ear. A composite skin graft can also be used to reconstruct amputated fingers or toes.

What Are the Indications of Skin Grafts?

Skin grafts can be used in a variety of medical conditions to address particular problems with compromised or injured skin. They are:

  • Areas where an infection has resulted in significant skin loss.

  • Burns.

  • Cosmetic or reconstructive surgery for skin injury or loss.

  • Surgery for skin cancer.

  • Unhealed venous ulcers.

  • Pressure ulcers.

  • Diabetic ulcers.

  • Significant wounds.

  • Surgical wounds that the surgeon was unable to adequately close.

  • In cases where bone is exposed due to tissue loss or infection.

  • Correct congenital skin defects.

  • Improving the appearance of scars

  • Reconstructing facial features after trauma or surgery.

What Are the Steps Involved in Skin Graft Healing?

As the transplanted skin interacts with the recipient site, a skin graft heals through multiple stages. The most important processes in skin transplant healing are as follows:

  • Plasmic Imbibition - After the graft is applied to the recipient location, the first stage is plasmatic imbibition. The graft might adhere to the wound bed when blood vessels in the recipient area start to take nutrients from the tissue of the transplant.

  • Inoculation - In the second stage, known as inoculation, blood vessels from the recipient site and the graft begin to join, allowing blood flow to start between the graft and the wound bed. The growth of new capillaries improves the graft's blood supply.

  • Revascularization - More blood vessels develop gradually, establishing blood flow between the graft and the surrounding tissue. The graft receives nutrition and oxygen, promoting its survival.

How Long Does It Take for Skin Graft Healing?

  • Imbibition occurs 24 to 48 hours after the treatment and is the initial stage of the skin transplant healing process. A thin layer of plasma and fibrin forms during imbibition to isolate the skin graft from the wound bed below. This film offers a moist environment that keeps the ischemia cells alive in the interim till a vascular supply is restored.

  • The second stage of skin transplant healing is inoculation. A small vascular network starts to develop within the fibrin layer 48 hours following the surgery. The dermis' surface is surrounded by new capillaries that permit the exchange of nutrients and oxygen.

  • The third step of skin transplant recovery is revascularization. It involves the invasion of fresh blood vessels. It may take up to a week for the three steps of skin transplant healing to complete.

What Are the Discharge Guidelines for the Skin Graft Site?

General Home Care

  • After the procedure, prepare to rest at home for up to a week.

  • Be prepared for some minor bleeding, pain, bruising, redness, and swelling.

  • Take any prescription pain medication exactly as directed.

  • Follow any additional instructions that were given by the doctor.

Caring for the Bandaged Graft Site

  • Avoid touching the bandage. Keep it in place until instructed to remove or replace it.

  • Keep the dressing dry. Use a sponge wash to prevent getting the bandage wet. Ask the doctor how to keep the dressing dry while washing or showering. Inquire with the doctor about what to do if the dressing gets wet.

  • Maintain a clean bandaged area. Keep dirt and sweat off of it.

  • Call the doctor if the bandage slips off, is damaged, or is very unclean.

  • Call the doctor if the tube on the vacuum bandage comes off.

  • Elevate the graft location above the level of the skin as much as feasible.

  • If the graft bleeds, place a clean cloth or bandage over the area for ten minutes while applying firm, mild pressure.

Taking Care of the Bandaged Donor Site

  • A small bandage will be applied to the donor site. Avoid touching the bandage. Keep it in place until instructed to remove or replace it.

  • This region will have a typical fluid leak.

  • Call the doctor if the spot gets swollen, hot, or painful.

  • After surgery, the dressing will be removed between seven and ten days.

  • The wound will be pink when the bandage is removed. It will gradually revert to its original color.

How to Take Care of the Skin After a Skin Graft?

  • Protection - In the early stages of recovery, newly healing skin grafts and donor sites are more sensitive than normal skin. It is therefore critical to safeguard these areas, particularly if someone is involved in an activity that could result in injury to these areas, such as playing contact sports.

  • Moisturizing - Donor sites and recently healed skin grafts may develop dryness and itching. These areas should be washed every day and moisturized up to three times every day. This improves the health and elasticity of the skin. When moisturizing, use vigorous circular strokes to assist in absorbing the moisturizing cream and soften the scarring.

  • Sunscreen - Newly healed skin grafts and donor sites are unable to protect themselves from sun damage. Therefore it is very important to avoid direct exposure to the sun as best as one can and to use a high-factor sunscreen at all times (at least factor 15 or above).


Patience, appropriate wound care, and following the medical recommendations are necessary for successful skin graft recovery. To get the greatest results possible, it is essential to collaborate closely with the healthcare team. Everyone's recovery process may be different. For the best results, always follow the healthcare provider's instructions.

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Dr. Dhepe Snehal Madhav
Dr. Dhepe Snehal Madhav



skin graft healing and aftercare
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