Do reproductive changes affect the TNBC risks?

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern. Factors that may increase the risk of triple-negative breast cancer (TNBC) (TNBC is an aggressive subtype that lacks estrogen, progesterone, and HER2 receptors) include:

1. A family history of breast cancer.
2. A personal history of breast cancer.
3. A personal history of breast conditions.
4. Beginning your period at a younger age.
5. Beginning menopause (natural end of a woman's menstrual cycles) at an older age.
6. Dense breast tissue.
7. History of drinking alcohol.

Other factors are as follows:

1. Age: Premenopausal women and those under the age of 50 have an increased risk of triple-negative breast cancer.
2. BRCA1 gene (breast cancer gene) mutation: About 70 percent of the breast cancers diagnosed in women with an inherited BRCA1 mutation are TNBC.
3. Ethnicity: African-American and Hispanic women have a higher rate of triple-negative breast cancers.
4. Triple-negative breast cancer is diagnosed with mammography (an X-ray imaging method used to examine the breast for the early detection of cancer and other breast diseases) and MRI (magnetic resonance imaging). Biopsy (procedure to remove cells, tissue, or fluid for medical examination purposes) and molecular testing (a laboratory method that uses a sample of tissue, blood, or other body fluid to check for certain genes, proteins, or other molecules), including IHC (immunohistochemistry) for ER (estrogen receptor), PR (progesterone receptor), and HER 2 neu (human epidermal growth factor receptor 2).
5. Triple-negative breast cancers are treated with chemotherapy (a common cancer treatment that uses medicines to destroy cancer cells and prevent tumor growth) and immunotherapy (a treatment that uses a person's immune system to fight cancer), and they usually respond well to this treatment.
6. Surgery and radiation therapy are parts that depend upon the stage and molecular profile.
7. After the treatment, one needs to make lifestyle changes, engage in physical activity, adopt a healthy diet, and regularly follow up with the oncologist (a doctor specializing in cancer treatment).
8. Pembrolizumab (a type of targeted therapy drug called an immune checkpoint inhibitor), when added with chemotherapy, improved outcomes in the management of breast cancer.

I hope this information will help you.

Kindly revert in case of queries.

Thank you.