I am 55. Is genomic testing needed for my breast cancer?

Question

Hello doctor,

I am a 55-year-old school principal who was recently diagnosed with early-stage breast cancer. My oncologist has suggested genomic testing to identify specific genetic mutations that could help guide treatment.

Please tell me,

What does this test involve?
How does it influence treatment decisions?
Does insurance typically provide coverage for it?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

One of the major components of the management plan is deciding on the most appropriate treatment to provide the best possible outcome and to help prevent recurrence. To achieve this, a key investigation is performed, such as genetic or genomic testing, as in your case.

This test analyzes multiple genes that are involved in the development of breast cancer, essentially defining the tumor biology. The results from genomic testing can determine the risk of recurrence, whether you would benefit from chemotherapy (antineoplastic agent), or which targeted therapy (biologic/antineoplastic agent) can be used in the treatment of your breast cancer.

Therefore, it is an important test in the overall management of breast cancer.

The most likely type of genomic testing that would be considered in your situation is the Mammaprint test. This test classifies the tumor based on the presence or absence of estrogen receptor (hormone receptor) and the presence or absence of human epidermal growth factor receptor 2, HER2 (receptor tyrosine kinase). Once this classification is made, appropriate treatment can be planned, and prognosis can also be estimated. Importantly, it helps in avoiding unnecessary treatment. One of the drawbacks of genomic testing is its cost, as it is often not covered by insurance.

I hope this helps.

Thank you.