Are the treatments for HR-ve and +ve breast cancer different?

Question

Hello doctor,

I am trying to understand more about HR-positive and HER2-negative breast cancer to raise awareness among my family, as my grandmom recently had the condition. What exactly does it mean to have hormone receptor-positive and HER2-negative breast cancer, and how does it differ from other types?

What are the typical treatment options for this specific subtype, and how effective are they? How do hormone therapies work in treating HR-positive breast cancer, and what should I expect in terms of side effects and outcomes?

Are there any new treatments or clinical trials available for this type of breast cancer? Additionally, how can lifestyle changes, such as diet and exercise, support treatment and improve overall outcomes?

Please help.

Answer 1

Hi,

Welcome to icliniq.com.

Breast cancer occasionally is hormone-driven; therefore, blocking those hormones will help in treating breast cancer. Two of the hormones commonly involved are estrogen and progesterone. So, when evaluating a breast lump and a biopsy is taken, these hormone receptors are accessed in the sample to determine if they are present or not. If they are present, the breast cancer is classified as HR-positive.

Additionally, HER2 also plays a role in breast cancer. It is also evaluated for. If it is absent, it is HER2 negative. This cancer carries a better prognosis and has more options for treatment than triple-negative breast cancer. The treatment option involves using hormones to block the receptors (hormonal therapy), thus inducing the death of the cancer cells and then the cure of the disease. It is quite effective, especially for the early stages of cancer.

Other options include surgery, radiotherapy, or chemotherapy. There are generally side effects, but they are not major and are often sorted out and managed effectively. One major risk factor for breast cancer is a family history. So, with a family member having breast cancer, it is pertinent that screening is taken more seriously amongst your mother and your other sisters. Generally, if cancer is detected early, the prognosis is very good, and the chances of achieving.

I hope this helps.

Thank you.