Patient's Query
Hello doctor,
I have resistant hyperpigmentation on my cheek area and have been using Tranexamic acid-based depigmenting treatment, which is known as Demelan, but I have noticed little to no improvement.
I am a 46-year-old woman, weigh approximately 165 pounds, and my height is 5 feet 4 inches.
Kindly advise on further treatment options and whether additional evaluation or alternative therapies may help improve my pigmentation. Please help.
Thank you.
Hi,
Welcome to icliniq.com.
I read your query.
I can truly understand how discouraging and emotionally draining cheek pigmentation can be, especially when you have already been diligent with treatments like Tranexamic acid and Demelan (a combination of Glycolic acid, Alpha-arbutin, and Kojic Acid dipalmitate, which is a gentle depigmenting cream that slowly lightens dark patches by reducing excess melanin production in the skin) and still have not seen the improvement you hoped for. Many patients in your situation feel the same frustration, and you are not alone in this.
Considering your age, which is 46 years, and the fact that the pigmentation is mainly confined to your cheeks, the pattern strongly suggests melasma (hormone- and sun-triggered dark patches on the face) or long-standing post-inflammatory hyperpigmentation (dark marks left behind after skin irritation or injury). These are very common conditions in women around this age and are known to be persistent and slow to fade, even with good treatment.
In your stage of life, pigmentation is often influenced by multiple overlapping factors, such as:
Daily sun exposure, even short or indirect exposure (walking outdoors, sitting near windows).
Hormonal changes that commonly begin in the mid-40s.
Genetic tendency, meaning your skin naturally produces more pigment.
Sensitive skin, where irritation easily triggers darkening.
Because these triggers work together, single creams alone often give limited results, which explains why Demelan did not give you enough improvement despite correct use.
This pigmentation is treatable, but it requires patience, consistency, and protection, rather than aggressive or rushed treatments. The goal is gradual lightening while protecting your skin from further damage.
For your skin type and pigmentation pattern, strict sun protection is non-negotiable:
Use a broad-spectrum sunscreen with SPF 50 (sunprotection factor) or higher every single morning.
Prefer a tinted sunscreen with iron oxides, as this blocks visible light that worsens melasma.
Even five to 10 minutes of unprotected sun exposure can reverse weeks of progress.
Your personalized step-by-step treatment plan is as follows:
Daily, in the morning, you can:
Cleanse with a gentle face wash to avoid irritation.
Apply a light, non-comedogenic moisturizer (will not clog pores).
Finish with a high-quality SPF 50+ sunscreen. Reapply if outdoors.
In the evening, for targeted treatment:
Twice a week only, use Melacare Forte cream, which contains a triple-action combination (Hydroquinone- reduces excess pigment, Tretinoin- helps old pigmented skin shed faster, Mometasone furoate- reduces inflammation and irritation.
This is known as the Kligman regimen and is specifically used for resistant melasma. It is effective but must be used carefully and for a limited time only.
On all other nights, continue Demelan cream, which gently slows down melanin (pigment) production, helping maintain results without irritating your skin.
After two months, stop Melacare forte and continue Demelan twice weekly for maintenance.
You can realistically expect gradual improvement over six to 12 weeks, with pigmentation fading slowly, and consistent use being more important than stronger products.
If needed later, procedures like chemical peels or low-energy lasers may help, but these should only be considered after careful evaluation, as aggressive procedures can worsen pigmentation in sensitive skin like yours.
You are already doing the right thing by seeking proper guidance instead of experimenting. Please reach out if you notice irritation, worsening patches, or if you simply need reassurance along the way. I am here to guide you through this.
I hope this helps.
Kindly revert so I can assist you further.
Thank you.
Same symptoms don't mean you have the same problem. Consult a doctor now!
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.