Lamotrigine medicine is sold under the brand name Lamictal, which is an anticonvulsant medication that is used to treat epilepsy and delay or prevent the recurrences of depressive episodes in bipolar disorder. In the case of epilepsy, Lamotrigine helps with tonic-clonic seizures, focal seizures, and seizures in Lennox-Gastaut syndrome.

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Can tapering off Lamictal cause heart attack or heart failure?

Query: Hi doctor,I am tapering off Lamictal, and have a question regarding this. I went from 200 mg to 175 mg. I have been doing this for a week now. When you are tapering off from Lamictal, can it in any way cause problems with the organs like heart failure, heart attack, seizures, etc.?I use Lamictal for...  Read Full »

Dr. Bn Bhagat

Answer: Hello, Welcome to Usually, Lamotrigine is tapered off when the patient's condition is stable. This is important. This decision is discussed between the patient and the doctor who has initiated the medicine. It should never be done by oneself. You should ask the guidance on tapering o...  Read Full »

Even after taking Lamictal, I have depression. Kindly help.

Query: Hi doctor, I am suffering from type 2 bipolar disorder. 10 years ago, I was diagnosed and treated for depression alone. I am a 42 year old female. I got married and have two kids. I stop the medication for five years and then I started to take it for the last one year. I am taking Lamictal 200 mg ev...  Read Full »

Dr. Aditya Gupta

Answer: Hello, Welcome to If Lamictal (Lamotrigine) is not helping much, then you can discuss with your treating doctor regarding either substituting it or adding another medicine for bipolar disorder. Certain non-pharmacological methods that will assist are as follows. Follow a flexible r...  Read Full »

I am taking Lamictal for bipolar disorder and gained weight. What can be done?

Query: Hi doctor, I was on Prozac for a few months. I loved it, but I experienced hypomania once. So, my psychiatrist switched me to Lamictal for bipolar disorder. I have gained weight and gotten depressed. Why am I gaining weight with this medicine?  Read Full »

Dr. Aditya Gupta

Answer: Hi, Welcome to Are you currently on Lamictal (Lamotrigine) alone or Lamictal plus Prozac (Fluoxetine)? Because, Prozac on long run can cause minor weight gain. Also, lack of physical activity during depression can cause weight gain. Simple changes in lifestyle like brisk morning walk an...  Read Full »

Will increased dose of Lamotrigine cause nocturnal seizures?

Query: Hi doctor, I have been diagnosed with temporal lobe epilepsy following a Tonic-Clonic seizure before nine years. From then before two years I was seizure-free having been put on Lamotrigine. Before two years I had another TC seizure and my dosage was raised (cannot remember the dose precisely), an...  Read Full »

Dr. Upendra K Shah

Answer: Hi, Welcome to As per the given information, I can understand that these symptoms are the effects of seizure, and unlikely to be due to Lamotrigine. The primary goal of the therapy is to control seizure episodes for which you have been prescribed Brivaracetam, you must start the new m...  Read Full »

What is the treatment option for bipolar 2 disorder with more depressive episodes?

Query: Hello doctor, I have bipolar disorder II and diagnosed with social and generalized anxiety disorders. Currently, my medication fails to uplift my depression. I take lithium 3x450 mg, Olanzapine 5 mg, Escitalopram 20 mg. Previously I tried Valproic acid, Carbamazepine, Topiramate, Zoloft, Prozac, C...  Read Full »

Dr. Parth Nagda

Answer: Hello, Welcome to Yes, bipolar depression is difficult to treat and it can be persistent. Many people do respond to a combination of Lamotrigine and Quetiapine (popularly called as Lami-quel). It takes time to act, but it is highly effective. Currently, I would suggest that instead ...  Read Full »

How to overcome the manic episodes caused by Cymbalta?

Query: Hello doctor, I recently was on Cymbalta minimum dose but did not feel better. I felt worse and was told to up the dose then I took 120 mg, still felt bad. So I abruptly stopped this and it triggered discontinue syndrome and hypermania. I have not felt the same since. I am not suffering so much now...  Read Full »

Dr. Aditya Gupta

Answer: Hello, Welcome to Considering the history of mania (even if it is drug-induced), it is not advisable to start Effexor alone in my opinion. So, I would suggest you discuss with your treating psychiatrist regarding starting Seroquel regularly as it also acts on depressive symptoms, or...  Read Full »

I am experiencing Lamictal withdrawal symptoms. Please help.

Query: Hi doctor, I have run out of Lamictal and the pharmacy will not open for the next two days. I am going to miss the dose for the next three nights. I am on Lamictal 200 mg at night along with two of Lorazepam. I have now terrified myself by reading internet chat groups. I also take Vyvanse and Effe...  Read Full »

Dr. Ashok Kumar Choudhary

Answer: Hi, Welcome to I read your query and understand your concerns. First of all, I like to assure you that internet chat groups are personal testimonials of individual persons and do not indicate in majority of cases what scientifically proved and same is applicable for Lamictal (Lamotrigin...  Read Full »

What are the drugs incompatible with Quetiapine and Lamotrigine?

Query: Hi doctor, My query is regarding the incompatibility of Quetiapine and Lamotrigine with other groups of drugs. Now I have to get treatment for an anaerobic infection. I was prescribed Azithromycin, Clindamycin, Metronidazole and Mycomax. However, I will be extremely grateful if you list me all grou...  Read Full »

Dr. Bharat Udey

Answer: Hello, Welcome to As such for Lamotrigine following drug interactions need to be considered as important. Valproate increases plasma level of Lamotrigine, hence dose need to be decreased if given with Valproate. Also there are increased chances of rash if given with Valproate. Ant...  Read Full »

How is fibromyalgia treated?

Query: Hello doctor, I am 61 year old and was lately diagnosed by a doctor as sick in fibromyalgia. In the last three years during the night time, I am suffering from aggressive involuntary movements while asleep. Those movements include kicking in the air and arching and bouncing my back and the whole bo...  Read Full »

Dr. Naval Mendiratta

Answer: Hello, Welcome to Well, these involuntary movements do not sound normal at all. It looks more of chorea/hemiballismus (movement disorder). It can be drug-induced but at the same time considering your age, we should get an MRI scan for the brain done. If any problem there, we will have...  Read Full »

Is Adderall safe during pregnancy?

Query: Hi doctor, I found out that I am 4 to 5 weeks pregnant. I am looking for some information about the safety of Adderall during pregnancy. Currently, I am taking Adderall XR 15 mg, Celexa 20 mg, and Lamictal 100 15 mg per day. I have a history associated with depression, anxiety and ADHD (attention ...  Read Full »

Dr. Amritagarwal

Answer: Hi, Welcome to Tablet Adderall (combination of Dextroamphetamine and Amphetamine) affects a grown persons heart rate but you are already taking in a very low dose of 15 mg per day and usually it is prescribed in a dosage of 20-28 mg per day. Tablet Celexa (Citalopram) falls under "ca...  Read Full »

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