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What is BCR-ABL positive and Ph-chromosome negative?
Query: Hello doctor, Can you please explain why I would have the gene and not the chromosome? Ph-negative, BCR-ABL-positive CML. The labs pointed to this. I had bone marrow aspiration and biopsy. I saw the doctor again. From all the labs, it looks like there is CD4 and CD8 elevated ratio 16.5, 8 % NK, lymp... Read Full »
Answer: Hello, Welcome to icliniq.com. Chronic myeloid leukemia (CML) is a hematopoietic disorder, almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11) or its variants. The Ph results in the formation of the BCR/ABL1 fusion gene, which is a const... Read Full »