What should be done to prevent complications in a pregnant woman who has tested positive for a few mutations?

Question

Hello doctor,

I had positive blood tests for the following mutations: factor XIII (heterozygous) and PAI-1 (675: 4G/4G, homozygous, and 844: AA, homozygous). My tests came negative (so there are no genetic mutations) for factor V Leiden, factor II (G20210A), and MTHFR. I am now 24 weeks pregnant and taking 162 mg of Aspirin daily. The baby seems to be doing fine.

What kind of complications will I have during the pregnancy?
What should I do to prevent such complications?

Kindly help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

The mentioned homozygous mutation can lead thrombosis event. The thrombotic event can lead to abortion. But your pregnancy is going well. So you might not have problems during your pregnancy. The thrombotic event can lead to placental insufficiency and intrauterine death of the fetus or preterm birth. But you are doing well in your pregnancy. So may need not worry. You have to continue the antithrombotic drug that is Aspirin. Regular antenatal check up and USG (ultrasonography) are to be done in your case.

Thank you.