Does compounded Semaglutide cause extreme fatigue and constipation?
Patient's Query
Hi doctor,
I recently started compounded Semaglutide from a wellness clinic. I am 61 years old with a BMI of 37, hypertension, prediabetes, and osteoarthritis, making exercise difficult. I have been on it for three weeks at 0.25 mg weekly with some concerning side effects. I am now experiencing extreme fatigue, severe constipation (no bowel movement for five days despite laxatives), and persistent headaches. I lost eight pounds already, which seems excessive in a short timeframe. Are these side effects normal or signs of impurity issues? Also noticed a black tarry stool, which is concerning. The clinic wants to increase my dose to 0.5 mg next week, but I am hesitant given the side effects. Should I request testing to verify what is actually in the medication? What safety questions should I ask the compounding pharmacy?
Please help me.
Thanks.
Hi,
Welcome to icliniq.com
I have read your query and can understand your concern.
It can be risky for patients to use unapproved versions of compounded “Semaglutide” because they do not undergo the FDA’s review for safety, effectiveness, and quality. They may be made by pharmacies that are not required to do surveillance, evaluation, or reporting of adverse events to the FDA.
Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
Check with your doctor right away if you have gaseous stomach pain, indigestion, recurrent fever, severe nausea or vomiting, stomach fullness, or yellow eyes or skin.
You can ask the compounding pharmacist where they get their Semaglutide, and check this FDA database to see if that factory is registered with the FDA. Licenses and registrations like this mean the facilities can be inspected and need to comply with safety and quality standards.
Reply to me if you have more concerns or questions.
I hope this information helps you.
Thank you.
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