What are the side effects of using compounded Semaglutide?
Patient's Query
Hi doctor,
I am a 45-year-old with PCOS, and my endocrinologist started me on compounded Semaglutide injections two weeks ago for weight management. The nausea is unbelievable. I have thrown up after every meal for three days straight. I have also noticed heart palpitations that wake me up at night. Is this level of side effects normal, or should I stop the medication? My pharmacy says everyone feels sick at first, but this seems extreme. I have already lost 8 pounds, but I am worried that something is not right with my body's reaction.
Please help me.
Thanks.
Hi,
Welcome to icliniq.com.
I can understand your concern.
Thank you for reaching out, and I appreciate you sharing these concerning symptoms. While nausea is a well-known side effect of Semaglutide, especially in the early weeks, vomiting after every meal for several consecutive days, coupled with heart palpitations, is not considered a typical or acceptable reaction and warrants immediate medical attention.
Semaglutide (including compounded forms) acts by slowing gastric emptying and affecting appetite centers in the brain, which can trigger nausea. However, persistent vomiting may lead to dehydration, electrolyte imbalances, and stress on the cardiovascular system, which might explain the palpitations you're experiencing at night. These are not symptoms to ignore.
In your case, the reaction appears more severe than expected, and it is possible that:
The dose is too high or escalated too quickly.
There may be an individual sensitivity to the medication or its compounded formulation.
Electrolyte disturbances or other side effects could be contributing to the palpitations.
Although initial weight loss may seem encouraging, your overall safety and well-being come first. I would strongly recommend stopping the injections for now and contacting your prescribing provider or seeking a medical evaluation as soon as possible.
Blood work (including electrolytes and cardiac markers) and possibly an ECG (electrocardiogram) may be necessary to rule out complications.
Also, keep in mind that compounded semaglutide formulations are not FDA-approved, and their potency and safety profiles may vary between pharmacies. If you continue this therapy in the future, it may be safer to do so with a brand-name formulation at a carefully titrated dose.
Please do not hesitate to seek urgent care if the vomiting persists or the palpitations worsen.
Thank you.
Same symptoms don't mean you have the same problem. Consult a doctor now!
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