HomeAnswersEndocrinologysemagluttide

What are the side effects of using compounded Semaglutide?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am a 45-year-old with PCOS, and my endocrinologist started me on compounded Semaglutide injections two weeks ago for weight management. The nausea is unbelievable. I have thrown up after every meal for three days straight. I have also noticed heart palpitations that wake me up at night. Is this level of side effects normal, or should I stop the medication? My pharmacy says everyone feels sick at first, but this seems extreme. I have already lost 8 pounds, but I am worried that something is not right with my body's reaction.

Please help me.

Thanks.

Answered by Dr. Aissa Youcef Mouffoki

Education:

Doctorate of Medicine

Professional Bio:

As a general practitioner deeply committed to holistic and accessible healthcare, I believe in treating patients as whole individuals—physically, mentally, and socially. My medical philosophy centers on prevention, patient education, and active listening, aiming to build trust and long-term well-being. I advocate for a more human, innovative approach to medicine, and regularly share insights with my community to empower and educate. I am fluent in Arabic, French, and English, which allows me to connect with and support a diverse patient population across cultures and regions.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

I can understand your concern.

Thank you for reaching out, and I appreciate you sharing these concerning symptoms. While nausea is a well-known side effect of Semaglutide, especially in the early weeks, vomiting after every meal for several consecutive days, coupled with heart palpitations, is not considered a typical or acceptable reaction and warrants immediate medical attention.

Semaglutide (including compounded forms) acts by slowing gastric emptying and affecting appetite centers in the brain, which can trigger nausea. However, persistent vomiting may lead to dehydration, electrolyte imbalances, and stress on the cardiovascular system, which might explain the palpitations you're experiencing at night. These are not symptoms to ignore.

In your case, the reaction appears more severe than expected, and it is possible that:

  1. The dose is too high or escalated too quickly.

  2. There may be an individual sensitivity to the medication or its compounded formulation.

  3. Electrolyte disturbances or other side effects could be contributing to the palpitations.

  4. Although initial weight loss may seem encouraging, your overall safety and well-being come first. I would strongly recommend stopping the injections for now and contacting your prescribing provider or seeking a medical evaluation as soon as possible.

  5. Blood work (including electrolytes and cardiac markers) and possibly an ECG (electrocardiogram) may be necessary to rule out complications.

  6. Also, keep in mind that compounded semaglutide formulations are not FDA-approved, and their potency and safety profiles may vary between pharmacies. If you continue this therapy in the future, it may be safer to do so with a brand-name formulation at a carefully titrated dose.

Please do not hesitate to seek urgent care if the vomiting persists or the palpitations worsen.

Thank you.

Ignoring similar symptoms could be risky.Share your symptoms and get personalised medical advice.Response in < 4 hours·Verified physicians·100% confidential
Medically reviewed by iCliniq medical review team
Published At August 1, 2025
Reviewed At August 6, 2025

Education:

Doctorate of Medicine

Professional Bio:

As a general practitioner deeply committed to holistic and accessible healthcare, I believe in treating patients as whole individuals—physically, mentally, and socially. My medical philosophy centers on prevention, patient education, and active listening, aiming to build trust and long-term well-being. I advocate for a more human, innovative approach to medicine, and regularly share insights with my community to empower and educate. I am fluent in Arabic, French, and English, which allows me to connect with and support a diverse patient population across cultures and regions.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

2,876Checks completed today
4.7/5User rating
~90 secAverage completion time
Evidence-basedGuideline aligned
Symptom Awareness Builder
Semaglutide Side Effects Awareness Builder

Experiencing severe semaglutide side effects?

Five quick questions help you understand if your reaction to compounded semaglutide is typical, warrants a mention to your doctor, or needs an immediate call.

For guidance only, not a diagnosis. Medications should be taken after consulting a physician. The dosages will be prescribed by the physician. Do not alter, start, or stop medications without consulting a healthcare professional.

Education:

Doctorate of Medicine

Professional Bio:

As a general practitioner deeply committed to holistic and accessible healthcare, I believe in treating patients as whole individuals—physically, mentally, and socially. My medical philosophy centers on prevention, patient education, and active listening, aiming to build trust and long-term well-being. I advocate for a more human, innovative approach to medicine, and regularly share insights with my community to empower and educate. I am fluent in Arabic, French, and English, which allows me to connect with and support a diverse patient population across cultures and regions.

This doctor is not available for online consultations on the platform anymore.

Listen to related tracks in our music library
Comprehensive Second Opinion

Ask your health query to a doctor online

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.