Can stopping Tezspire worsen asthma?

Hello,

Welcome to icliniq.com.

I can understand your concern.

That is a thoughtful question, and it is good that you are thinking ahead about what might happen if you stop treatment. Here is what you need to know. There is no known withdrawal effect from stopping Tezspire, which is the name for Tezepelumab-ekko. This means your body does not go into shock or experience rebound effects like it might with some steroids or other medications. Tezepelumab-ekko does not create dependency. However, symptoms can return over time. Tezepelumab-ekko works by suppressing a specific immune response; specifically, it blocks thymic stromal lymphopoietin (TSLP), a protein involved in airway inflammation. When you stop taking it, TSLP activity resumes, and over time, the inflammation in your airways can return. For most people, this results in a gradual worsening of symptoms such as increased shortness of breath, wheezing, or asthma flare-ups, rather than an immediate relapse. The timing varies; some individuals remain stable for a while, while others may notice their symptoms worsening within a month or two.

If you have experienced significant improvement on Tezepelumab-Gekko and then decide or need to stop, your doctor will likely monitor your condition closely and may adjust other medications, such as inhaled corticosteroids, to help manage your asthma. Common reasons for discontinuation can include insurance or cost-related issues, side effects, or infections (though these are rare, biologic medications like Tezepelumab-ekko are sometimes paused temporarily if you become ill). There is no special tapering or weaning process for stopping this medication; it typically involves simply skipping the next scheduled dose, with your doctor providing guidance on how to proceed from there.

I hope this helps.

Thank you.