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Can I use Tretinoin and glycolic acid together?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

Can I apply Ceutox serum and Cutiyt G12 together at night, and use Cutiyt in the morning before sunscreen?

Please suggest.

Answered by Dr. Misha Saghir

Education:

MBBS

Professional Bio:

Dr. Misha Saghir is a dedicated dermatologist with expertise in diagnosing and managing a wide range of skin, hair, nail, and cosmetic concerns. Her areas of expertise include acne, pigmentation, eczema, psoriasis, vitiligo, melasma, skin infections, and other hair and nail disorders. With previous experience as a general practitioner in government healthcare, Dr. Misha Saghir combines strong clinical knowledge with a patient-centered approach. She provides evidence-based online consultations, practical treatment plans, clear guidance, and appropriate follow-up care to help patients achieve healthy skin, hair, and nails.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

I understand your concern.

You can use Ceutox (Tretinoin) serum and Cutiyt G12 (Glycolic acid 12 percent) together, but with caution, because Glycolic acid is an exfoliating acid and incorrect layering can cause irritation. Cutiyt G12 contains Glycolic acid as its exfoliating agent and may cause mild irritation, especially when used with a topical retinoid such as Ceutox serum.

At night, apply Ceutox serum first to clean, completely dry skin. Use a small amount and allow it to absorb for 15 to 20 minutes. After that, apply Cutiyt G12 in a very thin layer, preferably only to areas with pigmentation rather than the entire face. If you notice burning, redness, or excessive dryness, do not layer them. Instead, use Ceutox on alternate nights and Cutiyt G12 on the remaining nights.

In the morning, you may apply Cutiyt G12 only if your skin tolerates it well; however, glycolic-acid–based creams are ideally restricted to nighttime use. If you do use it in the morning, wait 10 minutes and then apply a broad-spectrum sunscreen. Reapply sunscreen if you are outdoors. Do not use Ceutox serum in the morning.

Always use a gentle face wash, avoid scrubs, retinoids, or other acids while using Cutiyt G12, and moisturize if dryness occurs. Also, gently pat your face dry with a towel to avoid friction.

I hope this has helped you.

Please feel free to reach out to me again for further queries.

Thank you.

Medically reviewed by iCliniq medical review team
Published At April 2, 2026
Reviewed At April 6, 2026

Education:

MBBS

Professional Bio:

Dr. Misha Saghir is a dedicated dermatologist with expertise in diagnosing and managing a wide range of skin, hair, nail, and cosmetic concerns. Her areas of expertise include acne, pigmentation, eczema, psoriasis, vitiligo, melasma, skin infections, and other hair and nail disorders. With previous experience as a general practitioner in government healthcare, Dr. Misha Saghir combines strong clinical knowledge with a patient-centered approach. She provides evidence-based online consultations, practical treatment plans, clear guidance, and appropriate follow-up care to help patients achieve healthy skin, hair, and nails.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Misha Saghir is a dedicated dermatologist with expertise in diagnosing and managing a wide range of skin, hair, nail, and cosmetic concerns. Her areas of expertise include acne, pigmentation, eczema, psoriasis, vitiligo, melasma, skin infections, and other hair and nail disorders. With previous experience as a general practitioner in government healthcare, Dr. Misha Saghir combines strong clinical knowledge with a patient-centered approach. She provides evidence-based online consultations, practical treatment plans, clear guidance, and appropriate follow-up care to help patients achieve healthy skin, hair, and nails.

This doctor is not available for online consultations on the platform anymore.

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