Von Willebrand Factor

Von Willebrand factor, a blood glycoprotein that helps in hemostasis, is a carrier protein of factor VIII. The deficiency of this factor causes von Willebrand disease, thrombotic thrombocytopenic purpura, Heyde's syndrome, and hemolytic uremic syndrome. It helps the platelets to stick together, and they adhere to the wall of the blood vessels in a wound. These platelets form temporary clots and plug holes in blood vessels to stop bleeding.

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What can be done for the bruises on my daughter's leg that appear without injury?

Query: Hi doctor, This query is regarding my 8 year old daughter. She has been constantly getting bruises on her legs. We think this bruise occurs automatically and may not be due to injury. We have been noticing these bruises for the past 6 to 7 years. It fades away automatically after few days. We c...  Read Full »


Dr. Veerendra Channabasappa Patil

Answer: Hello, Welcome to icliniq.com. I have seen the attached reports (attachment removed to protect patient identity). Your description of the symptoms of your child seems to be significant, as the bruises are spontaneous. I would be interested to know the following points. Was there any swelling at the ...  Read Full »

Why did my sister get periods after six months?

Query: Hi doctor, My sister is 12.6 years old. She got her first period about six months ago. Just about four weeks ago, she got her second period. I know when you go through your first menstrual cycle it can be on and off, so that did not really bother me. But then, her second period just keeps coming ba...  Read Full »


Dr. Sonal Prasad

Answer: Hello, Welcome to icliniq.com. You are right. Periods can go haywire during puberty. One of the reasons for this heavy cycle is because it has come after six months and the uterus is getting rid of six months of the endometrium. It would be wise to visit a gynecologist to find out the causes of prol...  Read Full »

Are bleeding through the nose and underskin common in Von Willebrand disease?

Query: Hello doctor, I am a Von Willebrand disease (vWD) type 3 patient. I am currently bleeding through my nostrils, having underskin blood spots and pain in my ankle. These symptoms are new to me. Please help.  Read Full »


Dr. Prakash H. Muddegowda

Answer: Hi, Welcome to icliniq.com. Based on your query, my opinion is as follows: Bleeding is known to occur through nostrils and also in muscles, under skin, etc. An evaluation of Von Willebrand factor (vWF) levels is necessary to rule out any serious quantitative deficiency. Before that bleeding t...  Read Full »

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