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Cardiac Resynchronization Therapy - Types, Guidelines, and Risks

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Cardiac resynchronization therapy is a treatment to correct abnormal heart rhythms. This article is a brief overview of cardiac resynchronization therapy.

Medically reviewed by

Dr. Muhammad Zohaib Siddiq

Published At November 11, 2022
Reviewed AtNovember 15, 2022

Introduction

Heart failure is an increasing problem all over the world. Despite recent advances in cardiovascular therapy and treatment modalities, approximately 5,50,000 new cases are diagnosed every year. Of them, around 2,87,000 patients succumb to death. Irregular heart rhythms or arrhythmias can be induced due to various underlying cardiovascular events.

Factors that support arrhythmia include stress, age, medications, genes, and heart damage. Cardiac resynchronization therapy improves the rhythm and heartbeat in such compromised cases. This therapy first came into the picture in the 1990s and since then, has drastically changed the outlook of patients with congestive heart failure.

Cardiac resynchronization therapy restores the mechanical symphony of the heart by activating the heart through electrical means. Additionally, hearts that have failed can also be gotten back to improve their rhythm and function with the help of cardiac resynchronization therapy. The main reason to undergo cardiac resynchronization therapy is to alleviate symptoms of heart failure that are different in varying patients.

Who Is Cardiac Resynchronization Therapy For??

Cardiac resynchronization therapy has shown beyond doubt that it elevates the patient's cardiovascular functions and reduces heart failure symptoms. It increases the heart's capacity, thus helping the patient resume the day-to-day routine. Cardiac resynchronization therapy is suitable for patients with varying cardiac failure levels. It is also meant for patients whose different heart chambers do not work in unison. Patients with mild heart failure are not the candidate of choice who should receive cardiac resynchronization therapy. Patients with diastolic heart failure or those with no issues of different heart chambers not working in union are also included in this category of not receiving cardiac resynchronization therapy. Patients with underlying cardiovascular diseases who have never been treated for the same through therapy or drugs must not directly get into cardiac resynchronization therapy.

What Is a Cardiac Synchronization Therapy Device?

Cardiac synchronization therapy, or CRT, has shown clinical improvement in patients with heart failure. It is a proven treatment choice for such patients. The device used for cardiac synchronization therapy transmits a minute amount of electrical impulse to both the ventricular chambers of the heart. The heart is sectioned into four parts, two upper chambers called the atrium, and two lower chambers called ventricles. This transmitted impulse assists the lower chambers of the heart to beat simultaneously in a much more coinciding and synchronized manner. It is believed and proven that this stimulated configuration and synchroneity can enhance the heart’s capacity to pump and transport required blood and oxygen to the entire body.

What Are the Parts of a Cardiac Resynchronization Therapy Device?

Cardiac resynchronization therapy has proven to decrease the rate of mortality and events of heart failure. A cardiac synchronization therapy device consists of two main sections: the computer and the leads.

  • The computer for cardiac synchronized therapy is tiny in size and comes along with a battery. This is referred to as the heart device. This heart device contains miniature titanium-cased metals which are approximately the same size as that of a pocket watch.

  • The leads of a cardiac synchronization device are implanted to one’s heart. These are insulated wires whose primary work is to transfer inputs of information signals from the human heart to the heart device or the device’s computer. It also has another vital role in transporting electrical impulses to the human heart.

Once the cardiac synchronization device is inserted and put in place, an extrinsic computer which is positioned at the healthcare professional set up or the hospital or clinic where the therapy is taking place, is made use of to arrange the heart device with the help of programming. This external computer is referred to as a programmer. This programmer recovers the details and statistics from the heart device. This recovered information assists the healthcare professional and team in treating heart failure. The doctor schedules repeated monitoring and evaluation of the current heart condition.

Are There Different Types of Cardiac Resynchronization Devices?

Currently, there are two kinds of cardiac synchronization devices. They are the following:

  • Cardiac Resynchronization Therapy Pacemaker or CRT-P

  • Cardiac Resynchronization Therapy Defibrillator or CRT-D

Either of these is indicated based on the condition and severity of the ongoing cardiac failure.

What Are the Guidelines Followed for Cardiac Resynchronization Therapy?

The AHA or American Heart Association guidelines represent the categories that are indicative of using cardiac resynchronization therapy on patients with varying levels of heart failure. The categorized guidelines are mentioned as follows:

  • Indicated or Class 1- Cardiac resynchronization therapy is suggested since they show symptoms even after medical treatment.

  • Reasonable or Class 2a - Cardiac resynchronization therapy may be considered for patients who are already under medical treatment.

  • May be considered, or Class 2b - Cardiac resynchronization therapy may be regarded alongside ongoing implantation.

  • Not indicated or Class 3 - Cardiac resynchronization therapy is not considered since the patient is asymptomatic and has a chronic non-cardiac condition.

What Are the Risks of Cardiac Resynchronization Therapy?

The associated risks of this therapy are minimal. Rarely there occurs an infection at the surgery site or a failure of the device. There are certain limitations post-therapy that are related to magnetic fields, radiations, gas-powered appliances, etc.; your healthcare provider will establish the dos and don'ts post-therapy.

Conclusion

Cardiac resynchronization therapy benefits patients with congestive heart failure and has evidently improved patient life quality. There is yet a large number of patients who have not been acquainted with cardiac resynchronization therapy and are undergoing medication therapy to cure congestive heart failure. Identification of patients who must receive cardiac resynchronization therapy is essential. Only then will the therapy show its full potential. Patients also have the option to continue their cardiovascular medications if necessary and if suggested by the physician. By undergoing cardiac resynchronization therapy, it is predicted that the outcome is positive in the long run.

Frequently Asked Questions

1.

What Is an Example of a Cardiac Resynchronization Therapy Device?

Cardiac resynchronization therapy (CRT) involves the implantation of a device known as a biventricular pacemaker. The right and left ventricles of the heart get electrical signals from this device, which helps them beat in unison and increase the effectiveness of pumping blood. One such CRT device is the Medtronic CRT-D, which treats heart failure and prevents potentially fatal arrhythmias by combining CRT with a defibrillator function. Patients with heart failure can live much better lives thanks to CRT.

2.

What Are the Different Types of Cardiac Resynchronization Therapy Devices Available?

Cardiac resynchronization therapy (CRT) comes in two main types:
- Cardiac Resynchronization Therapy-Pacemaker (CRT-P): This device does not include a defibrillator feature; its main purpose is to resynchronize the heart's ventricles by pacing.
- Cardiac Resynchronization Therapy With Defibrillation(CRT-D): This device can treat life-threatening arrhythmias with defibrillation in addition to ventricular resynchronization.
While CRT-D provides additional protection against potentially harmful arrhythmias, both CRT-P and CRT-D seek to improve heart function and symptoms in patients with heart failure. The particular needs and conditions of the patient will determine which option is best.

3.

What Are the Key Differences Between Cardiac Resynchronization Therapy (CRT) And a Pacemaker?

The following are the main differences between a standard pacemaker and cardiac resynchronization therapy (CRT):
- Function: The main function of a pacemaker is to control heart rate and rhythm, whereas CRT aims to synchronize the heart's ventricles to improve pumping efficiency.
- Target Patients: While pacemakers treat a wider spectrum of heart rhythm abnormalities, CRT is usually utilized for those with heart failure, especially those who have electrical conduction issues.
- Leads: To achieve resynchronization, CRT requires implanting leads in both ventricles, although a conventional pacemaker might just have one lead.
- Effect: Compared to a conventional pacemaker, CRT may be able to reduce the symptoms of heart failure and possibly improve the patient's quality of life. The decision is based on the needs and particular cardiac state of the patient.

4.

How Does Cardiac Resynchronization Therapy (CRT) Differ From an Implantable Cardioverter-Defibrillator (ICD)?

The main goals of an implanted cardioverter-defibrillator (ICD) and cardiac resynchronization therapy (CRT) are different:
- Heart failure is treated by CRT, which synchronizes ventricular contractions to enhance heart function, while ICDs identify and rectify potentially fatal arrhythmias with electrical shocks.
- Leads are usually inserted into both ventricles during CRT in order to resynchronize, but ICDs also use leads for monitoring and the delivery of defibrillation shocks as necessary.
- Patients with heart failure may receive a CRT-D device, which combines CRT and ICD functions for comprehensive treatment.

5.

What Medical Conditions or Symptoms Indicate the Need for Cardiac Resynchronization Therapy (CRT)?

1. Heart Failure: Especially in individuals who have a lower ejection fraction and still have symptoms after receiving the best medical care possible.
2. Ventricular Dyssynchrony: Ineffective heart pumping results from the ventricles' delayed electrical activation.
3. Symptoms: When patients continue to have symptoms, including exhaustion, exercise intolerance, and shortness of breath, despite receiving normal heart failure therapies, CRT may be advised.

6.

How to Describe the Typical Procedure Involved in the Implantation of a Cardiac Resynchronization Therapy Device?

The standard process for implanting a Cardiac Resynchronization Therapy (CRT) device is as follows:
- Placement of Leads: On the left side of the heart, the coronary sinus vein, the right atrium, and the right ventricle are all reached by thin cables called leads.
- Implantation of the Device: Usually, in the area of the collarbone, a tiny pulse generator is placed beneath the skin. It is wired to the leads and set up to fire off coordinated bursts of electricity.
- Testing and Adjustment: Following implantation, the device is put to the test to make sure that the heart's chambers are synchronized properly. If needed, changes are made to improve cardiac performance.

7.

Who Qualifies as a Suitable Candidate for Cardiac Resynchronization Therapy (CRT)?

The following people are usually suitable candidates for Cardiac Resynchronization Therapy (CRT):
- Have symptomatic heart failure with reduced ejection fraction (HFrEF) despite optimal medical therapy.
- Show signs of ventricular dyssynchrony, which are typically picked up by an ECG.
- Fulfill particular requirements set by their healthcare professional, taking into account things like the severity of their symptoms and their unique cardiac characteristics.

8.

What Type of Pacemaker Is Typically Used for Cardiac Resynchronization Therapy, and How Does It Function?

Cardiac Resynchronization Therapy (CRT) typically involves the use of a biventricular pacemaker. Three leads make up this unique pacemaker: one each in the right atrium, ventricle, and coronary sinus vein on the left side of the heart. The apparatus synchronizes the contractions of both ventricles by delivering electrical impulses at precisely the right time. In doing so, it enhances the heart's pumping efficiency and helps people with ventricular dyssynchrony and heart failure feel better.

9.

Why Is Cardiac Resynchronization Therapy (CRT) Commonly Used in the Treatment of Heart Failure?

Cardiac Resynchronization Therapy with a pacemaker and an ICD (CRT-D) is commonly used in the treatment of heart failure because it addresses both heart failure symptoms and the risk of sudden cardiac death. By offering a holistic approach to managing heart failure and potentially fatal arrhythmias, the device can identify and treat hazardous heart rhythms with a more potent shock than a typical pacemaker, improving the overall prognosis for patients suffering from these illnesses.

10.

What Potential Risks or Complications Should Patients Be Aware of When Considering CRT?

Patients who are thinking about CRT should be informed of the following possible risks and issues:
- Infection: The location of device implantation is susceptible to infection, which may necessitate antibiotic therapy or device removal.
- Hematoma or Bleeding: Although rare, hematoma, bleeding, or bruises at the surgery site are possible.
- Lead Displacement: Device functionality may be impacted by misplaced leads, which may need to be replaced or repositioned. Before receiving CRT, patients should talk about these risks with their healthcare professional.

11.

Can Cardiac Resynchronization Therapy Enhance Overall Survival Rates in Patients With Heart Failure?

Yes, individuals with heart failure who receive cardiac resynchronization therapy (CRT) have higher overall survival rates. It has been demonstrated to lower mortality and enhance prognosis in heart failure patients, especially in those with ventricular dyssynchrony and reduced ejection fraction. Improved survival results are a result of CRT's ability to maximize cardiac function, reduce symptoms, and lower the risk of complications due to heart failure.

12.

Where in the Body Is a Cardiac Resynchronization Therapy (CRT) Device Typically Implanted?

Usually, a cardiac resynchronization therapy (CRT) device is placed close to the collarbone, under the skin of the upper chest. The leads that go through veins and are placed inside the heart are what link the device to the chambers of the heart. During the implantation process, a subcutaneous pocket is made, and the device generator is inserted into it.

13.

What Is Considered a Normal Outcome or Result After Undergoing Cardiac Resynchronization Therapy (CRT)?

A normal outcome or result after undergoing Cardiac Resynchronization Therapy (CRT) typically includes:
- Heart failure patients frequently report enhanced exercise tolerance, lower shortness of breath, and higher energy levels as a result of their condition.
- The goal of CRT is to synchronize contractions of the ventricles in order to improve pumping efficiency and maybe raise the ejection fraction.
- A lot of patients report feeling better overall and in terms of their physical capabilities.

14.

Is It Possible for Cardiac Resynchronization Therapy (CRT) To Reverse the Effects of Heart Failure in Some Cases?

In certain instances, a better prognosis overall and even partial heart function recovery may come through ventricular contraction synchronization, enhanced cardiac function, and symptom relief. Not every case of heart failure can be completely reversed by CRT, and individual differences may exist in the degree of improvement and reversibility.
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Dr. Muhammad Zohaib Siddiq
Dr. Muhammad Zohaib Siddiq

Cardiology

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