Hi, Welcome to icliniq.com. I read your query and understand your concern. Tukysa (Tucatinib) is a tyrosine kinase inhibitor of HER2 (a protein that causes cancer to grow fast). In vitro, Tucatinib inhibits phosphorylation of HER2 and HER3, resulting in inhibition of downstream MAPK (mitogen-activated protein kinase) and AKT (protein kinase B) signaling and cell proliferation, and shows anti-tumor activity in HER2-expressing tumor cells. Tuksya is a smaller molecule than Trastuzumab, so it can target the part of HER2 on the inside of cancer cells.
Hello, Welcome to icliniq.com. I understand your concern and will address each point clearly: AI (artificial intelligence) technology in urology: AI-powered imaging tools, such as MRI (magnetic resonance imaging) fusion biopsy, use artificial intelligence to analyze images and pinpoint suspicious areas. These tools can improve the accuracy of biopsies and help avoid unnecessary procedures. However, AI is not a replacement for a biopsy but a complementary tool that enhances diagnosis. Reliability: AI-assisted diagnosis is promising but still developing.
Hi, Welcome to icliniq.com. Firstly, FNH (focal nodular hyperplasia) is a benign condition, as you have already explained. Secondly, blood pressure in the range of 90/60 mmHg is quite common in teenage females. Before surgery, she will undergo some routine tests to rule out any other abnormality, which can lead to hypotension, such as anemia, hypothyroidism, etc. If all of these investigations are normal, one may proceed with the surgery.
Hello, Welcome to icliniq.com. Thanks for writing in, and I understand your concern. We have to evaluate the patient regarding his overall clinical status. If it is an emergency surgery, we have to weigh the risks and benefits of the surgery. So, in this case, I need more information about the patient, like his comorbidities, what kind of surgery he needs, his cardiac status, and the primary disease for which he needs chemotherapy.
Hello, Welcome to icliniq.com. You do not have to worry at all. Having a sinus issue is not a contraindication for anesthesia. You can have sedation supplemented with local anesthetics. In case you need endotracheal intubation, that will be safer for you because your nasal passage will be bypassed, and you can be totally knocked off, which is called general anesthesia.
Hello, Welcome to icliniq.com. Regarding your query, your surgery can be done under spinal or epidural anesthesia. It is a much safer option than general anesthesia. You will be pain-free for hours after surgery. You will be absolutely awake during surgery and will not be able to move your legs even a bit.
Hello, Welcome to icliniq.com. You may have atypical pseudocholinesterase deficiency (a rare genetic disorder that makes people extremely sensitive to certain muscle relaxants used during general anesthesia) due to a heterozygous mutation, which is hereditary. Pseudocholinesterase is an enzyme responsible for the metabolism of certain anesthetic drugs like succinylcholine and the ester group of local anesthetics. Your Dibucaine level is 81 L, which is quite normal. But still, some drugs can be avoided if you require anesthesia.
Hello, Welcome to icliniq.com. Regarding your query, THC (tetrahydrocannabinol) does not trigger malignant hyperthermia (a type of severe reaction that occurs in response to particular medications used during general anesthesia). However, episodes of cannabis-induced psychosis, especially after the use of higher potency THC formulations, can co-present with fever, tachycardia (a fast heart rate), and hypertension. These symptoms could be mistaken for other conditions with similar symptom clusters like malignant hyperthermia, serotonin syndrome (a potentially life-threatening drug reaction that results from having too much serotonin in your body), neuroleptic malignant syndrome (a rare but life-threatening reaction that can occur in response to antipsychotic medications), 3,4-methylenedioxymethamphetamine overdose, or thyrotoxicosis (a rare but severe and life-threatening complication of hyperthyroidism). These symptoms are prominent after withdrawal.
Hello, Welcome to icliniq.com. I appreciate that you have chosen icliniq.com for your medical needs. One thing you forgot to mention is what surgery have you planned for. For patients taking tablet Buprenorphine (Subutex), if it is a minor surgery, then there is no need to stop the tablet Buprenorphine (Subutex).
Hello, Welcome to icliniq.com. Coming to your query, the efficacy of local anesthesia depends on various factors like the expertise of the anesthetist, drugs used, adjuvants, the amount of drug used, etc. For a small and uncomplicated hernia, local anesthesia with sedation is a preferred technique, and you can be discharged at the earliest. If you still feel pain or discomfort during the surgery, it can be converted into general anesthesia. So, you do not have to worry, just have faith in your anesthesiologist.
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