Is Tezspire effective for non-eosinophilic asthma?

Hello doctor,

I am reaching out regarding my 16-year-old daughter, who suffers from severe and uncontrolled asthma that does not respond to conventional treatments. She is currently prescribed Symbicort and Montelukast, yet she still requires prednisone bursts nearly every month. Her pulmonologist has recently suggested that she start receiving Tezspire (tezepelumab) injections, as her eosinophil levels are not high enough to qualify for other biologic therapies. This year alone, she has missed 32 days of school due to asthma exacerbations, and her most recent episode necessitated a four-day hospitalization, including a brief stay in the ICU. We have made efforts to remove all known triggers from our home environment.

I have two inquiries: First, is Tezspire effective for cases of non-eosinophilic asthma when other treatments have proven ineffective? Second, what are the long-term safety implications for a teenager using this medication? The financial burden is significant, even with our insurance coverage, as we face a monthly copay of $1,200. However, witnessing her struggle to breathe is truly distressing, and we are willing to make financial sacrifices if this treatment could genuinely provide her with relief.

Kindly help.