"Alpha thalassemia refers to an inherited blood disorder that causes a reduction in hemoglobulin production. It typically occurs due to the deletion of the HBA1 and HBA2 genes. These two genes provide instructions to make a protein called alpha-globin, a component of hemoglobulin. There are four types of alpha thalassemia- alpha thalassemia silent carrier, alpha thalassemia carrier, Hemoglobulin H disease, and alpha thalassemia major. People with thalassemia have anemia, weakness, fatigue, enlarged liver or spleen, yellowish skin, and leg ulcers. Treatment of thalassemia may include daily doses of folic acid, blood transfusions, surgery to remove the spleen, and iron chelation therapy.
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Query: Hello doctor, The attached PDF are the results from CBC tests and Hb electrophoresis of a girl baby. The first CBC was done in one month, and the following CBC and Hb electrophoresis tests were done in two years of age. The tests seem to indicate that the girl is (at least) a carrier of the alpha th... Read Full »
Answer: Hello, Welcome to icliniq.com. Hemoglobin constant spring is non-deletional alpha thalassemia. This abnormal hemoglobin results from point mutation at the stop codon of the α2-globin gene (TAA > CAA) which leads to the addition of 31 amino acids to a normal α-globin sequence. The heterozygous ... Read Full »
Query: Hi doctor, My son was diagnosed as a carrier of alpha thalassemia. I did the blood test report to check whether myself or his mother are the cause. Can you check the whole report for me and tell me what are the issues in this report? Read Full »
Answer: Hi, Welcome to icliniq.com. I understand your concern. Your child is having alpha thalassemia carrier. So one of the parents might have an alpha thalassemia carrier. For that DNA analysis which means molecular testing is needed. Through these analyses, gene deletion can be diagnosed. Based on you... Read Full »
Query: Hello doctor, My wife is nine weeks pregnant with our first child. We got are hemoglobin results back today. My wife's test results were positive. EA, HbE trait with or without thalassemia. I would like to know if child's health could be a concern? Please help. Her grandmother has diabetes. Got it a... Read Full »
Answer: Hello, Welcome to icliniq.com. HbE trait will not pose any health problems to your child if he or she inherits it. Only the size of the red blood cells will be smaller than normal. The only worrying aspect is the fact that your wife might have the alpha thalassemia gene which might affect your bab... Read Full »
Query: Hi doctor, I am a thalassemia carrier patient with an alpha trait, and my girlfriend also has the same thalassemia trait issue. Moreover recently I got diagnosed with neutropenia. My question is should I continue with the relationship with my girlfriend? Would it cause any problem, for our future ge... Read Full »
Answer: Hello, Welcome to icliniq.com. I read your query and can understand your concern. In beta thalassemia condition, two minor couple marriage is not advisable. But in alpha thalassemia, the mechanism is somewhat complex because the alpha chain contains four gene alleles. So it has to be checked how man... Read Full »