How can amyloidosis be managed in elderly people?

Question

Hello doctor,

My granddad has been diagnosed with amyloidosis. I have been trying to learn more about it, but it is all so confusing and scary. From what I have read, it is a rare condition where abnormal proteins called ‘amyloids’ build up in different organs and tissues, causing damage. In my granddad's case, they said the amyloids were affecting his heart and kidneys. He has been so tired and weak lately, and now we know why. However, I still do not fully understand what causes these amyloid buildups or how they treat amyloidosis. The doctors mentioned something about misfolded proteins, but it went right over my head. Can you shed some light on this disease for me?

Kindly suggest.

Answer 1

Hi,

Welcome to icliniq.com.

Thank you for choosing us as your healthcare provider.

I have gone through all your details and appreciate your concern.

Amyloidosis is a rare disease that occurs when an abnormal protein called amyloid builds up in organs and tissues, disrupting their normal function.

Types of amyloidosis:

Primary amyloidosis: The most common type, caused by abnormal plasma cells in the bone marrow producing amyloid light chains.
Secondary amyloidosis: Results from chronic inflammatory diseases such as rheumatoid arthritis or inflammatory bowel disease.
Hereditary amyloidosis.
Senile amyloidosis: Due to age-related changes leading to amyloid deposits.

Symptoms depend on the organs affected:

Heart: Fatigue, shortness of breath, swelling of the legs, and irregular heartbeats.
Kidneys: Protein in the urine, swelling in the legs and around the eyes, and kidney failure.
Nervous system: Numbness, tingling, and pain in the hands or feet.
Digestive system: Diarrhea, constipation, and difficulty swallowing.

Diagnosing involves:

Blood and urine tests: To detect abnormal proteins.
Biopsy: A tissue sample.
Echocardiogram, and MRI (magnetic resonance imaging).

Treatment:

Depends on the patient and requires a physical examination by a doctor.

I hope that you get your answer. Please let me know if you need some help.

Thank you.