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Should I stay on antidepressants long-term at 48?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I have been on sertraline for a little over four years now. I started at 50 mg, and it has been at 100 mg for the past two years. Things are genuinely better than before, and I function okay day to day, but I am 48 now and starting to wonder if I need to be on this medication forever. My psychiatrist has not pushed me either way, and I do not know how to even bring it up.

Should I stay on antidepressants long-term at 48, and is there a point where coming off is actually safe, or will I just spiral again if I try?

Please help.

Thank you.

Answered by Dr. Ashraf Ghani

Education:

MD

Professional Bio:

Dr. Ashraf Ghani Niazai is a GMC-certified General Medicine Specialist, recognized by the prestigious General Medical Council (UK). With extensive experience in diagnosing and managing a wide range of acute and chronic health conditions, he combines advanced medical knowledge with genuine compassion for his patients. He is skilled in internal medicine, obstetrics and gynecology, dermatology, preventive healthcare, and lifestyle management, always focusing on personalized, evidence based care to achieve the best possible outcomes. As an inspiring medical educator, he has taught thousands of medical students and contributed multiple research publications to the field of medicine, reflecting his commitment not only to treating patients but also to advancing medical science. Patients value his warm approach, clear communication, and dedication to their long term health and well being.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I have read your query and understand your concern

I am glad to hear that you are doing better, and it is completely understandable to wonder about the future after taking sertraline for several years.

There is no single answer; the decision to continue or gradually stop an antidepressant depends on how many episodes of depression you have had, their severity, how long you have been well, whether you have ongoing risk factors for relapse, and how well you tolerate the medication.

Many people safely remain on antidepressants for years if the benefits continue to outweigh any downsides, while others are able to slowly taper off under the guidance of their psychiatrist after a sustained period of stability.

Feeling well may mean the medication is working, so it is important not to stop it suddenly. It would be a sensible idea to tell your psychiatrist exactly what you shared here and ask whether you might be a suitable candidate for a carefully monitored taper.

If you do decide to try coming off, it should be done gradually with close follow-up so any return of symptoms can be recognized early. Whatever the decision, the goal is to help you maintain your mental health and quality of life in the safest way possible.

So please try to follow up if you feel this answer would be helpful for you.

And I hope you will feel better soon.

Thank you.

Medically reviewed by iCliniq medical review team
Published At July 9, 2026
Reviewed At July 13, 2026

Education:

MD

Professional Bio:

Dr. Ashraf Ghani Niazai is a GMC-certified General Medicine Specialist, recognized by the prestigious General Medical Council (UK). With extensive experience in diagnosing and managing a wide range of acute and chronic health conditions, he combines advanced medical knowledge with genuine compassion for his patients. He is skilled in internal medicine, obstetrics and gynecology, dermatology, preventive healthcare, and lifestyle management, always focusing on personalized, evidence based care to achieve the best possible outcomes. As an inspiring medical educator, he has taught thousands of medical students and contributed multiple research publications to the field of medicine, reflecting his commitment not only to treating patients but also to advancing medical science. Patients value his warm approach, clear communication, and dedication to their long term health and well being.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MD

Professional Bio:

Dr. Ashraf Ghani Niazai is a GMC-certified General Medicine Specialist, recognized by the prestigious General Medical Council (UK). With extensive experience in diagnosing and managing a wide range of acute and chronic health conditions, he combines advanced medical knowledge with genuine compassion for his patients. He is skilled in internal medicine, obstetrics and gynecology, dermatology, preventive healthcare, and lifestyle management, always focusing on personalized, evidence based care to achieve the best possible outcomes. As an inspiring medical educator, he has taught thousands of medical students and contributed multiple research publications to the field of medicine, reflecting his commitment not only to treating patients but also to advancing medical science. Patients value his warm approach, clear communication, and dedication to their long term health and well being.

This doctor is not available for online consultations on the platform anymore.

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