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Will my COPD-asthma symptoms be relieved with biologics?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am a 60-year-old man with severe asthma overlapping with COPD (chronic obstructive pulmonary disease). I often wake up breathless at night and have already been hospitalized twice in the past year for exacerbations. I am on high-dose inhaled steroids with a LABA (long-acting beta agonist), but symptoms persist. My doctor mentioned biologics like Mepolizumab.

1. How do doctors determine eligibility for biologics, and are there special risks for patients with COPD overlap?

2. Are pulmonary rehabilitation and breathing exercises truly helpful in improving long-term outcomes?

Please suggest.

Thank you.

Answered by Dr. Kanishka Sharma

Education:

MBBS

Professional Bio:

Dr. Kanishka Sharma is a dedicated general practitioner committed to healing both hearts and minds. She believes the best doctors offer their compassion before their prescriptions, and she strives to provide care that is gentle, thorough, and truly patient-centered. Her approach blends medical knowledge with empathy, ensuring every patient feels heard and supported.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

Dealing with persistent breathlessness despite being on strong medication is frustrating and frightening, especially after being hospitalized. Let us address your concerns directly.

For eligibility for biologics like Nepolizumab, we consider biologics when standard treatments, like your high-dose inhalers, are not enough to control symptoms and prevent severe flare-ups. The main factor we look for is evidence of a specific type of inflammation in your airways, often linked to a high level of a certain white blood cell (called an eosinophil) in your blood or sputum.

The decision is more nuanced for patients with asthma and COPD (chronic obstructive pulmonary disease) overlap. We proceed carefully to ensure the biologic targets the right kind of inflammation. The risks are similar, but we monitor you closely to ensure the treatment is effective for your condition.

Pulmonary rehabilitation and breathing exercises are good. They are not just advice; they are a core part of treatment. They are essential for training your breathing muscles and overall stamina. Pulmonary rehabilitation will not reverse the disease, but it is proven to significantly improve quality of life, reduce breathlessness, and give you techniques to manage episodes when they happen. It can also help lower your chances of being hospitalized again.

The next step is for us to review your recent blood tests and the pattern of your symptoms to see if a biologic is an appropriate option for you. In the meantime, I strongly recommend a referral to a pulmonary rehabilitation program.

I hope this answers your query.

Let me know if I need to assist you further.

Thank you.

Medically reviewed by Dr. K. Shobana
Published At November 23, 2025
Reviewed At November 23, 2025

Education:

MBBS

Professional Bio:

Dr. Kanishka Sharma is a dedicated general practitioner committed to healing both hearts and minds. She believes the best doctors offer their compassion before their prescriptions, and she strives to provide care that is gentle, thorough, and truly patient-centered. Her approach blends medical knowledge with empathy, ensuring every patient feels heard and supported.

This doctor is not available for online consultations on the platform anymore.

Education:

BDS

Professional Bio:

Dr. K. Shobana is a Dental Surgeon specializing in oral health and dental care. She is skilled in preventive dentistry and provides oral hygiene education. She can do restorative treatments such as fillings and crowns. She can handle periodontal problems such as gum diseases and periodontitis. She can do root canal treatment.

This doctor is not available for online consultations on the platform anymore.

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Education:

MBBS

Professional Bio:

Dr. Kanishka Sharma is a dedicated general practitioner committed to healing both hearts and minds. She believes the best doctors offer their compassion before their prescriptions, and she strives to provide care that is gentle, thorough, and truly patient-centered. Her approach blends medical knowledge with empathy, ensuring every patient feels heard and supported.

This doctor is not available for online consultations on the platform anymore.

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