Will my COPD-asthma symptoms be relieved with biologics?
Patient's Query
Hello doctor,
I am a 60-year-old man with severe asthma overlapping with COPD (chronic obstructive pulmonary disease). I often wake up breathless at night and have already been hospitalized twice in the past year for exacerbations. I am on high-dose inhaled steroids with a LABA (long-acting beta agonist), but symptoms persist. My doctor mentioned biologics like Mepolizumab.
1. How do doctors determine eligibility for biologics, and are there special risks for patients with COPD overlap?
2. Are pulmonary rehabilitation and breathing exercises truly helpful in improving long-term outcomes?
Please suggest.
Thank you.
Hello,
Welcome to icliniq.com.
I have read your query and can understand your concern.
Dealing with persistent breathlessness despite being on strong medication is frustrating and frightening, especially after being hospitalized. Let us address your concerns directly.
For eligibility for biologics like Nepolizumab, we consider biologics when standard treatments, like your high-dose inhalers, are not enough to control symptoms and prevent severe flare-ups. The main factor we look for is evidence of a specific type of inflammation in your airways, often linked to a high level of a certain white blood cell (called an eosinophil) in your blood or sputum.
The decision is more nuanced for patients with asthma and COPD (chronic obstructive pulmonary disease) overlap. We proceed carefully to ensure the biologic targets the right kind of inflammation. The risks are similar, but we monitor you closely to ensure the treatment is effective for your condition.
Pulmonary rehabilitation and breathing exercises are good. They are not just advice; they are a core part of treatment. They are essential for training your breathing muscles and overall stamina. Pulmonary rehabilitation will not reverse the disease, but it is proven to significantly improve quality of life, reduce breathlessness, and give you techniques to manage episodes when they happen. It can also help lower your chances of being hospitalized again.
The next step is for us to review your recent blood tests and the pattern of your symptoms to see if a biologic is an appropriate option for you. In the meantime, I strongly recommend a referral to a pulmonary rehabilitation program.
I hope this answers your query.
Let me know if I need to assist you further.
Thank you.
Same symptoms don't mean you have the same problem. Consult a doctor now!
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.
