How safe and effective are biologics for asthma and COPD?

Question

Hello doctor,

I am a 46-year-old woman living with severe asthma and early-stage COPD. Despite using inhalers daily, I often experience shortness of breath, even with minimal physical activity. I also frequently wake up at night due to coughing.

My doctor has recommended biologic injections, and I would like to know more about their safety for women and whether they are suitable for long-term use. Additionally, I am wondering if quitting smoking and losing weight could improve my breathing. My goal is to reduce the frequency of these flare-ups and improve my overall quality of life. Please help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

I completely understand your concerns.

It sounds like you may have a condition known as asthma COPD (chronic obstructive pulmonary disease, a long-term lung disease that makes it hard to breathe due to airflow obstruction) overlap, which can absolutely be managed with the right treatment plan. There are several effective strategies to help improve your breathing and overall well-being.

Biologic injections can be a very effective option, especially when asthma remains severe despite regular inhaler use. These treatments are generally safe for women and are suitable for long-term use when monitored by a healthcare provider. Many patients experience fewer flare-ups, reduced reliance on steroid tablets, and an overall improved quality of life.

Quitting smoking is one of the most impactful steps you can take. Smoking worsens both asthma and COPD and reduces the effectiveness of inhalers and biologic therapies. The benefits of quitting begin within weeks and can significantly slow the progression of lung damage.

Losing excess weight can also make a meaningful difference. Even a modest weight loss of five to 10 % can help your lungs expand more freely, reduce breathlessness, and enhance your quality of life.

Nighttime coughing is a sign that your airways are still sensitive. It is essential to ensure your inhaler technique is correct and to minimize exposure to common irritants, such as dust, incense, cold air, and low indoor humidity. Staying up to date with vaccinations such as flu, pneumococcal, and COVID-19 boosters can also help prevent infections that often trigger flare-ups.

Lastly, it is important to manage any related conditions, such as sinusitis or acid reflux, as these can contribute to ongoing coughing and worsen respiratory symptoms.

I hope this helps.

Kindly revert if there is any query.

Thank you.