Are people with severe asthma good candidates for biologics?

Question

Hello doctor,

I have severe asthma and have been hospitalized twice in the past six months, despite being on high-dose inhalers. Someone recently mentioned biologic treatments such as Mepolizumab and Benralizumab. I would like to know if these medications can actually prevent asthma attacks or if they only help reduce the symptoms. What kind of testing or evaluation is required to determine whether I am a suitable candidate for these treatments? Additionally, are there any known long-term side effects associated with these injections? I am just hoping to breathe normally again and improve my quality of life.

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

Thank you for your message and for sharing your concerns so openly. I can understand how frustrating and exhausting it must be to struggle with asthma despite being on high-dose inhalers and experiencing repeated hospitalizations. Allow me to address your questions and explain the options that may help improve your condition.

What are biologics, and can they stop asthma attacks?

Biologic therapies, such as Mepolizumab and Benralizumab, are advanced treatments specifically designed for severe eosinophilic asthma. This is a subtype of asthma that is characterized by elevated levels of eosinophils, which are a type of white blood cell that contributes to inflammation in the airways.

Although biologics do not cure asthma, they can significantly reduce the frequency and severity of asthma attacks. They may also improve lung function and reduce the need for oral corticosteroids. Many patients who begin treatment with biologics report substantial improvements in their breathing and overall quality of life.

How do I know if I am a candidate for biologics?

To determine whether you are eligible for biologic therapy, your healthcare provider will typically recommend several evaluations, including:

A blood test to measure eosinophil levels.
Pulmonary function testing (such as spirometry).
Allergy testing, if indicated.
A detailed review of your asthma history, including current medications, level of control, and frequency of exacerbations.

If your eosinophil count is elevated and your asthma remains poorly controlled despite the use of high-dose inhalers and other standard treatments, you may be a strong candidate for biologic therapy.

What about the long-term safety of biologics?

Biologic medications such as Mepolizumab and Benralizumab are generally well tolerated. The most commonly reported side effects are mild and may include injection site reactions, headaches, or fatigue. Serious adverse effects are rare, and these medications have demonstrated a favorable safety profile in long-term clinical studies. Regular follow-up appointments are important to monitor your response to treatment and to detect any potential side effects early.

What are the next steps?

If you have not already done so, I recommend consulting a pulmonologist or an asthma specialist. They can assess your asthma phenotype and determine whether you are a good candidate for starting biologic therapy. These treatments are usually administered via injection every four to eight weeks, depending on the specific medication prescribed.

You deserve to experience relief from your symptoms and to breathe freely again. With an appropriate and personalized treatment plan, that goal is achievable. Please do not hesitate to reach out if you have any further questions or if you would like assistance with arranging the next steps in your care.

I hope this helps you.

Take care.