Does Tezepelumab help in improving asthma and flare-ups?

Question

Hello doctor,

I am 56 and have been struggling with asthma despite using strong inhalers for years. My recent tests showed worsening lung function, and my doctor suggested trying Tezpire. I still experience severe attacks, with my oxygen levels dropping to 85 % during a flare-up, and it took hours to recover even after using the nebulizer.

Is Tezspire significantly more effective than other biologics for cases like mine?
What are the risks associated with it?
How often does it work for severe asthma patients?

I am looking for a solution to reduce my frequent hospital visits.

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

Tezspire is a monoclonal antibody that targets thymic stromal lymphopoietin (TSLP), a key driver of inflammation in asthma. It is approved for treating severe asthma and has shown promising results in clinical trials.

Benefits over other biologics:

Improved lung function: Tezspire has been shown to enhance lung function, reducing asthma symptoms and exacerbations.
Reduced exacerbations: Clinical studies demonstrate a significant reduction in severe asthma flare-ups.
Broader eligibility: Unlike some biologics, Tezspire is not limited to specific biomarkers or asthma phenotypes, making it suitable for a wider range of patients.

Risks and side effects:

Allergic reactions: Rare but potentially severe allergic reactions can occur.
Increased risk of parasitic infections: Tezspire may increase the risk of infections like strongyloidiasis.
Common side effects: Headache, fatigue, and injection site reactions have been reported in clinical trials.

Efficacy in severe asthma: Tezspire has been effective for patients with severe asthma, particularly those with:

Uncontrolled symptoms: Significant improvements in symptoms and quality of life.
Frequent exacerbations: Studies show a reduction in the frequency of severe flare-ups.

Next steps: To optimize your treatment plan:

Share reports: Please provide your most recent pulmonary function tests (PFTs), allergy test results, and any relevant medical records.
Regular monitoring: Regular pulmonary function tests (PFTs) will help track your lung function and adjust treatment as needed.
Inhaler technique: Ensure proper inhaler technique and adherence to your medication plan. Using a spacer or inhaler with a counter may help improve delivery.

Please send your reports and schedule a follow-up appointment to discuss your treatment options.

I hope this answers your query.

Please let me know if I can assist you further.

Thank you.