What are the effects of Tezspire on asthma?

Question

Hello doctor,

A 35-year-old female patient with severe asthma is contemplating the use of Tezspire. The patient has previously failed five biologic treatments, including Dupixent and Omalizumab. Current laboratory results indicate a blood eosinophil count of 600 and a fractional exhaled nitric oxide (FeNO) level of 85 ppb. The patient is experiencing weekly bursts of prednisone, which are negatively impacting mental health. A recent hospitalization necessitated the use of BiPAP (bilevel positive airway pressure). The patient's current Asthma Control Test (ACT) score is 8. Additionally, there is a history of chronic rhinosinusitis and eosinophilic granulomatosis with polyangiitis (CRS/EGPA). Although insurance has approved the treatment, there are concerns regarding its efficacy due to the history of multiple failures with biological therapies.

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

To gain a clearer understanding of your condition, please submit the following comprehensive clinical history and reports:

Clinical History

1. Asthma background: Indicate the age of onset, severity, and any past hospitalizations or admissions to the intensive care unit (ICU).

2. CRS/EGPA background: Provide the date of diagnosis, associated symptoms, treatments received, and their outcomes.

3. Previous biologic therapies: List the biologics you have used (including Dupixent and Omalizumab), along with their dosages and the duration of each treatment.

4. Current symptoms: Detail your asthma symptoms, specifying their frequency, severity, and any known triggers.

Recent Blood Reports

Complete Blood Count (CBC): Submit your latest CBC report, highlighting the white blood cell count, eosinophil count, and hemoglobin levels.
Erythrocyte Sedimentation Rate (ESR): Provide the most recent ESR report.
Immunoglobulin E (IgE): Share your latest IgE report.

Pulmonary Function Tests (PFTs)

Spirometry: Present your most recent spirometry report, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio.
Lung volumes: Submit the latest lung volume report, detailing total lung capacity (TLC), residual volume (RV), and functional residual capacity (FRC).

Medication History

Current medications: List your current medications, including their dosages and administration frequencies.
Previous medications: Provide a list of past medications, along with their dosages and frequencies.

Additional Information

Allergies: Indicate any known allergies.
Family history: Share any pertinent family medical history.

This information will assist me in understanding your situation more thoroughly and in offering more personalized recommendations.

Managing severe asthma can be quite difficult, particularly when previous biologic treatments have not been successful. Here are some key points and considerations:

About Tezspire:

Mechanism of action: Tezspire works by targeting thymic stromal lymphopoietin (TSLP), a cytokine that plays a role in the inflammatory process. This unique mechanism may provide advantages even when other biologics have not been effective.
Efficacy in biologic-experienced patients: Clinical studies have demonstrated Tezspire's effectiveness in individuals who have not responded to other biologics, such as Dupixent and omalizumab.
Blood eosinophil and FeNO levels: Your elevated blood eosinophil count (600) and FeNO level (85ppb) suggest persistent inflammation, which Tezspire may help to mitigate.

I hope this information helps you.

Thank you.