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What do you think about GemCarbo chemotherapy?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Sivanath

Medically reviewed by

iCliniq medical review team

Published At November 10, 2016
Reviewed AtOctober 19, 2019

Patient's Query

Hello doctor,

My mother has been diagnosed with stage 4 adenocarcinoma. She was having trouble breathing due to pleural fluid buildup. As per our oncologist's suggestion we have started Gemcitabine-Carboplatin chemotherapy before 10 days. The suggested course of treatment is six cycles of chemotherapy. As the test for EGFR mutations was not successful, the doctors did not suggest Erlotinib based treatment such as Tarceva. Can we switch to Erlotinib after two cycles of chemotherapy without knowing whether EGFR is positive or not?

Answered by Dr. sivanath

Hi,

Welcome to icliniq.com.

I can understand your anxiety.

  • By the EGFR (epidermal growth factor receptor) not been successful, do you mean that the test was not positive for mutations or it could not be performed due to inadequacy of the sample? Please clarify.
  • Starting EGFR inhibitors in the absence of mutation is not recommended as there will be no benefit and the patient will lose important time in which she could have received chemotherapy.
  • If the sample is inadequate and it is strongly recommended to get a rebiopsy, then continue chemotherapy till then.

Revert back with the answer to the above question to a medical oncologist online --> https://www.icliniq.com/ask-a-doctor-online/medical-oncologist

Patient's Query

Thank you doctor,

Biopsy was done twice, but the tissue sample was not adequate to do further studies. So, doctors suggested to just continuing with chemotherapy. What do you think of the GemCarbo chemotherapy? Will that be effective? What else can we do to improve life expectancy? Our doctors are giving 6 to 9 months. What do you say?

Answered by Dr. sivanath

Hi,

Welcome back to icliniq.com.

  • GemCarbo is a decent option, since Pemetrexed cannot be given due to pleural effusion.
    • If it is stage IV, then there are usually ample number of sites from where an adequate sample can be taken like liver if she has a gross plural effusion, even that can be tapped and send for tissue block formation.
      • That tissue block can be used to study genetic analysis. This is much less invasive than deep tissue biopsy and commonly practiced. Patients are more compliant to this.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. sivanath
Dr. sivanath

Internal Medicine

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