Cyclophosphamide

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Does protein leak from the larger filter of kidney in nephrotic syndrome?

Query: Hi doctor, I heard that in nephrotic syndrome the filtering unit of kidney becomes larger and so protein comes in urine. I am a patient of cortisone dependent nephrotic syndrome over 15 years. Doctor says that about 95 percent of children will get cured at the age of 18. I am 17 years old now. When...  Read Full »


Dr. Anshul Varshney

Criticalcare Physician, Diabetologist, General Medicine Physician, Internal Medicine Physician, Medical Gastroenterologist, Nephrologist, Pulmonologist, Rheumatologist

Answer: Hi, Welcome to icliniq.com. Yes, you have heard the things right. Due to increased pore there is protein in urine. The best treatment remains the Cortisone. In cases where there is no response to Cortisone as evidenced by persistence of albumin in urine, we need to shift those patients on Cyclopho...  Read Full »

What does borderline positive c-ANCA levels indicate?

Query: Hello doctor, My c-ANCA levels are 5.6 U/ml (borderline positive). I have hypertension and proteinuria (3g), high serum creatinine (2.4) and UTI. My other autoimmune tests and serum electrophoresis results are negative. What should I do and what is the general prognosis?  Read Full »


Dr. Anshul Varshney

Criticalcare Physician, Diabetologist, General Medicine Physician, Internal Medicine Physician, Medical Gastroenterologist, Nephrologist, Pulmonologist, Rheumatologist

Answer: Hi, Welcome to icliniq.com. Based on your query, my opinion is as follows: C-ANCA (Antineutrophil cytoplasmic antibodies) positivity indicates Wegener's Granulomatosis. In this condition, there is involvement of upper and lower respiratory tract and kidneys. Most common diagnosis, while kidneys a...  Read Full »

My sister has swelling, cushingoid facies and proximal myopathy. Why?

Query: Hi doctor, My sister is 37 years old with previous 2 LSCS. She has symptoms such as swelling over whole body and face. Along with these complaints she has weakness, tiredness, cushingoid facies, proximal myopathy, palpitation, trembling of hands and amenorrhea or slight on and off spotting. She is s...  Read Full »


Dr. Anshul Varshney

Criticalcare Physician, Diabetologist, General Medicine Physician, Internal Medicine Physician, Medical Gastroenterologist, Nephrologist, Pulmonologist, Rheumatologist

Answer: Hello, Welcome to icliniq.com. I checked your sister's complete details (attachments removed to protect patient identity). She is suffering from relapsing nephrotic syndrome. Her cushingoid facies and proximal myopathy are steroid induced as you must be already knowing. Gradually replacing the ster...  Read Full »

My son has nephrotic syndrome with focal segmental glomerulosclerosis. Please advice.

Query: Hello doctor, My 12 year old son is suffering from nephrotic syndrome since the last seven years. Two years ago, when his biopsy was done, the result said FSGS. His creatinine levels at that time was 4. Now it is raised to 10.1. He is currently taking Calcium, Folic acid, Pantoprazole, Sodium bicar...  Read Full »


Dr. Geeta Priyadarsini Kamminana

General Medicine Physician, Internal Medicine Physician

Answer: Hello, Welcome to icliniq.com. Please furnish the following medical information, so that I will be able to give you further advice. What is the cause of focal segmental glomerulosclerosis (FSGS)?Has dialysis been done? What is his urine output?What does his antinuclear antibody (ANA) profile say?Ha...  Read Full »

How to treat my mother's vasculitis?

Query: Hi doctor, My mother has been suffering from vasculitis. She is facing difficulty in walking. She also has thyroid, diabetes and sarcoidosis. Currently, she is on Covance 50, Gabantin 100, Dilzem 30, Raricap, Sympta 20 and Modlip 10. For vasculitis, she was prescribed to have Wysolone 7.5 mg and Mmf...  Read Full »


Dr. Naval Mendiratta

Rheumatologist

Answer: Hi, Welcome to icliniq.com. Well, there is a lot of treatment available for vasculitis (blood vessel inflammation). We do use injection Cyclophosphamide and Rituximab. But, it is very difficult to comment anything unless you tell us which vasculitis is she suffering from as the treatment will vary a...  Read Full »

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