My son has nephrotic syndrome with focal segmental glomerulosclerosis. Please advice.

Hello,

Welcome to icliniq.com.

Please furnish the following medical information, so that I will be able to give you further advice.

1. What is the cause of focal segmental glomerulosclerosis (FSGS)?
2. Has dialysis been done? What is his urine output?
3. What does his antinuclear antibody (ANA) profile say?
4. Has he been treated with steroids?
5. Is he on immunosuppressive agents like Cyclophosphamide or Azathioprine?

• Do attach his biopsy and ultrasound reports as well. I will wait for the same.

Revert with more information to an internal medicine physician online --> https://www.icliniq.com/ask-a-doctor-online/internal-medicine-physician

Hello,

Welcome back to icliniq.com.

• From the reports (attachment removed to protect patient identity), it clinically appears to be steroid-resistant nephrotic syndrome (SRNS) with a tissue diagnosis of FSGS with calcineurin inhibitor (CNI) toxicity. The treatment is challenging. There are experimental therapies though.
• Can you please provide me a recent renal biopsy report with immunofluorescence microscopy? Also, kindly attach the latest urine protein, lipid profile, urine microscopy, and sediment examination for my clarity. Treatment can be planned only after seeing the recent biopsy report. If the reports show FSGS, I suggest giving him Rituximab with continuous monitoring.
• If the FSGS progressed to diffuse global glomerulosclerosis and contracted kidneys, he might need a renal transplantation. Take care.

For more information consult an internal medicine physician online --> https://www.icliniq.com/ask-a-doctor-online/internal-medicine-physician