Q. My son has nephrotic syndrome with focal segmental glomerulosclerosis. Please advice.

Answered by
Dr. Geetha Priyadarsini Kamminana
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jun 14, 2017 and last reviewed on: Oct 21, 2021

Hello doctor,

My 12 year old son is suffering from nephrotic syndrome since the last seven years. Two years ago, when his biopsy was done, the result said FSGS. His creatinine levels at that time was 4. Now it is raised to 10.1. He is currently taking Calcium, Folic acid, Pantoprazole, Sodium bicarbonate and Cilnidipine. Please suggest the course of action.



Welcome to

Please furnish the following medical information, so that I will be able to give you further advice.

  1. What is the cause of focal segmental glomerulosclerosis (FSGS)?
  2. Has dialysis been done? What is his urine output?
  3. What does his antinuclear antibody (ANA) profile say?
  4. Has he been treated with steroids?
  5. Is he on immunosuppressive agents like Cyclophosphamide or Azathioprine?
  • Do attach his biopsy and ultrasound reports as well. I will wait for the same.

Revert with more information to an internal medicine physician online -->

Hello doctor,

Thanks for replying. No, he did not undergo any dialysis previously. His urine output is normal. He has been treated with steroids like Omnacortil, Deflazacort, Cyclophosphamide, Tacrolimus, and Mycophenolate mofetil. The cause of FSGS might be Tacrolimus because he was on it when the creatinine levels went up. I have attached his latest reports for your consideration.



Welcome back to

  • From the reports (attachment removed to protect patient identity), it clinically appears to be steroid-resistant nephrotic syndrome (SRNS) with a tissue diagnosis of FSGS with calcineurin inhibitor (CNI) toxicity. The treatment is challenging. There are experimental therapies though.
  • Can you please provide me a recent renal biopsy report with immunofluorescence microscopy? Also, kindly attach the latest urine protein, lipid profile, urine microscopy, and sediment examination for my clarity. Treatment can be planned only after seeing the recent biopsy report. If the reports show FSGS, I suggest giving him Rituximab with continuous monitoring.
  • If the FSGS progressed to diffuse global glomerulosclerosis and contracted kidneys, he might need a renal transplantation.  Take care.

For more information consult an internal medicine physician online -->

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Prednisolone is the only solution for my rectal bleeding. How long can I take it?

.. suggests that you have steroid-dependent ulcerative colitis. So you rightly started Azathioprine and I think it should work if you are taking a proper dose (you have not shared dose of Azoran and your body weight). You can take Azoran as 1.5-2.5 m...   Read full

Test QA 1 checking in Page Title

Hi doctor, I am 27 years old. I have a 5 months baby (cesarean). The baby and I are fine. From day one, he is fit. There is no health issues since his birth. And I did not have any health issues after delivery of our first baby. I got pregnant again...   Read full

When will swelling due to nephrotic syndrome in a baby reduce?

Hi doctor, I am 27 years old. I have a 5 months baby (cesarean). The baby and I are fine. From day one, he is fit. There is no health issues since his birth. And I did not have any health issues after delivery of our first baby. I got pregnant again...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

The New COVID Variant From South Africa (Omicron)
The World Health Organisation has enlisted Omicron to be a variant of concern. Just scroll down the article to know abou...  Read more»
Managing Diabetes During Festive Season
All the festivals are indirectly a danger sign for diabetic patients. Read this article to know more about how to handle...  Read more»
What You Should Eat and Drink for A Healthy Life!!
Food is essential for our survival, and what we eat definitely impacts our health. We can easily reduce the risk of many...  Read more»

Ask your health query to a doctor online?

Ask an Internal Medicine Physician Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.