HomeAnswersInternal Medicinenephrotic syndromeWhat is the treatment for focal segmental glomerulosclerosis in a 12-year-old?

My son has nephrotic syndrome with focal segmental glomerulosclerosis. Please advice.


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At June 15, 2017
Reviewed AtJune 6, 2023

Patient's Query

Hello doctor,

My 12 year old son is suffering from nephrotic syndrome since the last seven years. Two years ago, when his biopsy was done, the result said FSGS. His creatinine levels at that time was 4. Now it is raised to 10.1. He is currently taking Calcium, Folic acid, Pantoprazole, Sodium bicarbonate and Cilnidipine. Please suggest the course of action.


Welcome to icliniq.com.

Please furnish the following medical information, so that I will be able to give you further advice.

  1. What is the cause of focal segmental glomerulosclerosis (FSGS)?
  2. Has dialysis been done? What is his urine output?
  3. What does his antinuclear antibody (ANA) profile say?
  4. Has he been treated with steroids?
  5. Is he on immunosuppressive agents like Cyclophosphamide or Azathioprine?

Patient's Query

Hello doctor,

Thanks for replying. No, he did not undergo any dialysis previously. His urine output is normal. He has been treated with steroids like Omnacortil, Deflazacort, Cyclophosphamide, Tacrolimus, and Mycophenolate mofetil. The cause of FSGS might be Tacrolimus because he was on it when the creatinine levels went up. I have attached his latest reports for your consideration.


Welcome back to icliniq.com.

  • From the reports (attachment removed to protect patient identity), it clinically appears to be steroid-resistant nephrotic syndrome (SRNS) with a tissue diagnosis of FSGS with calcineurin inhibitor (CNI) toxicity. The treatment is challenging. There are experimental therapies though.
    • Can you please provide me a recent renal biopsy report with immunofluorescence microscopy? Also, kindly attach the latest urine protein, lipid profile, urine microscopy, and sediment examination for my clarity. Treatment can be planned only after seeing the recent biopsy report. If the reports show FSGS, I suggest giving him Rituximab with continuous monitoring.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Geetha Priyadarsini Kamminana
Dr. Geetha Priyadarsini Kamminana

Internal Medicine

Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Ask your health query to a doctor online

Internal Medicine

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy