Are my low testosterone and depression linked to each other?

Question

Hello doctor,

I have low testosterone and have been taking Desvenlafaxine for treatment. I have also been struggling with depression for the past five years. I would like guidance on managing both conditions together and understanding if my low testosterone could be contributing to my mood issues.

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I understand that you have been dealing with low testosterone while taking Desvenlafaxine for depression over the past five years. Low testosterone can result from several factors, including hormonal imbalance, stress, certain medical conditions, or sometimes as a side effect of long-term illness or medication.

To get a clear picture, it is important to confirm your testosterone levels and overall hormonal health with proper blood tests, ideally done in the morning (8 to 10 a.m.). These should include:

Total and free testosterone.
LH (luteinizing hormone), FSH (follicle-stimulating hormone), and prolactin (to check pituitary function).
Thyroid function (TSH, also known as thyroid-stimulating hormone).
Liver and kidney function.
Fasting blood glucose and lipid profile.

These tests help determine whether your low testosterone is primarily from the testes or due to another hormonal pathway.

Please continue taking Desvenlafaxine as prescribed, do not stop it abruptly, as that can worsen mood symptoms. If you notice fatigue, low energy, or sexual side effects, discuss them with your psychiatrist, as adjustments may help.

Meanwhile, lifestyle measures can support hormone balance:

Regular exercise, especially resistance or strength training.
Sufficient sleep.
Balanced diet.
Limiting alcohol.

I hope this answers your query.

Please let me know if I can assist you further.

Thank you.