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I have eczema. Can stress flare its symptoms?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am 27 and have had eczema since childhood, mainly behind my knees and elbows. Recently, itching has become very bad at night, and sleep has been disturbed almost daily. The doctor prescribed Atarax tablets for itching. It works, but the next morning I feel very sleepy and slow at work.

  1. Is it fine to take Atarax daily for the long term, or will the body get used to it?

  2. Also, I noticed flares during stressful weeks or when my sleep is poor. Can stress really make eczema worse, or is it just a coincidence?

Please help.

Hello,

Welcome to icliniq.com.

I understand your concern.

I am sorry you are dealing with this. Long-standing eczema can be especially frustrating when the itching becomes intense enough to disturb sleep.

The areas you mentioned, behind the knees and inside the elbows, are classic sites for atopic dermatitis, the most common form of eczema that often begins in childhood and can continue into adulthood.

People with this condition frequently experience dry skin, red or darker inflamed patches, severe itching, and sometimes thickened skin from repeated scratching.

Nighttime itching is particularly common because body temperature and inflammatory signals tend to rise at night, and there are fewer distractions, which makes the itch sensation feel stronger.

Unfortunately, this can lead to a cycle of itch, scratching, skin irritation, and more itching, which also explains why sleep becomes disrupted. The medication your doctor prescribed, Atarax (which contains Hydroxyzine), is an antihistamine often used to help control severe itching, especially at night.

One of its main effects is sedation, which is why it can help people fall asleep despite the itching. However, the downside, exactly what you noticed, is morning drowsiness, slowed thinking, or feeling groggy, especially if the dose is higher or taken late at night.

Taking Hydroxyzine occasionally or during flare periods is generally considered safe for many people, but using it daily for long periods is not always ideal because of the persistent sedation and the possibility that your body may gradually become less responsive to its anti-itch effect.

Some dermatologists manage this by adjusting the dose, using it only during severe flare-ups, or sometimes switching to a less sedating antihistamine during the day while keeping Hydroxyzine for nighttime itching.

If the morning sleepiness is affecting your work, it would be reasonable to discuss dose adjustment or alternative options with your doctor.

Your observation about stress and poor sleep triggering flares is actually very well recognized in eczema. Psychological stress activates the body’s stress hormone system (such as cortisol and adrenaline) and can also influence immune pathways in the skin.

In people with atopic dermatitis, these changes can increase skin inflammation and itching, which can trigger or worsen flare-ups. Stress can also make people scratch more unconsciously, particularly during sleep, which further damages the skin barrier.

So what you are noticing during stressful weeks is very likely not a coincidence; many patients with eczema report the same pattern. Poor sleep can worsen the cycle as well, because sleep deprivation increases inflammatory signals in the body and makes the skin more reactive.

I hope you find this helpful.

Thank you.

Answered byDr. Ashraf Ghani

Medically reviewed byiCliniq medical review team

Published At April 8, 2026
Reviewed AtApril 8, 2026

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