Q. What can be done for Eisenmenger syndrome and severe pulmonary hypertension?

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The lesions in Eisenmenger syndrome, such as large septal defects, are characterized by high pulmonary pressure and/or a high pulmonary flow state. Development of the syndrome represents a point at which pulmonary hypertension is irreversible and is an indication that the cardiac lesion is likely inoperable. The cardiac arrhythmias and sudden cardiac death are important late complications of this syndrome. Conservative management with medications and/or lung and cardiac transplantation are therapeutic approaches that can offer quality-of-life improvement.