Hemoglobin A2

Hemoglobin A2, a normal variant of hemoglobin A, contains two alpha and two delta chains. It occurs in low levels in normal blood. It appears in excess in beta-thalassemia. Elevated HbA2 also occurs in hyperthyroidism and folate deficiency. They help in the formation of alpha-globin protein.

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Kindly go through my blood report and suggest the type of thalassemia.

Query: Hi doctor,I have attached a report. I just want to know if this hemoglobin electrophoresis result is beta thalassemia minor or beta thalassemia intermedia or beta thalassemia major.  Read Full »


Dr. Parth R Goswami

Answer: Hi, Welcome to icliniq.com. According to HPLC report (high-performance liquid chromatography), you have attached, HbA2 raised and HbA decreased (hemoglobin A2 and A). Hence, it is suggestive towards thalassemia minor (attachment removed to protect patient identity). It does not look like thalassemi...  Read Full »

How is the prognosis of a child with abnormal hemoglobin pattern?

Query: Hi doctor, My friend is going to adopt a 6 months old female child. Certain routine tests were performed on the child. I have attached the reports for your reference. The Hb electrophoresis for thalassemia screening is showing an abnormal hemoglobin pattern. The treating pediatrician is not sure abo...  Read Full »


Dr. Prakash H. Muddegowda

Answer: Hi, Welcome to icliniq.com. Based on your query and attached report (attachment removed to protect patient identity), my opinion is as follows: Looking at the report of HbD trait (hemoglobin D), the prognosis is excellent. The child will be very rarely transfusion dependent and mostly asymptomatic. ...  Read Full »

Am I a beta-thalassemia carrier with the hemoglobin A2 level of 4.3?

Query: Hello doctor, I was just wondering for a second opinion on some results which I have received being 8+4 weeks pregnant. My FBC was normal but my hemoglobin A2 Level is 4.3 and it says the normal range is 1.5 to 3.6. But I just wanted to know if this definitely means I am a carrier of beta-thalassem...  Read Full »


Dr. Parth R Goswami

Answer: Hi, Welcome to icliniq.com. Your attached CBC report shows normal hemoglobin and MCV with RBC count is also within range (attachment removed to protect patient identity). I have calculated Mentzer index as well which is also not in favor of thalassemia minor. Moreover, in the report, also it has b...  Read Full »

Can you please go through my electrophoresis report and tell me if I have thalassemia minor?

Query: Hi doctor, Could you please go through my reports and tell me if I have thalassemia minor? I have attached my electrophoresis test reports. Some of the values in the report are Hb F - 0.8 %, Hb adult - 66.0 %, Hb A2 - 30.8 % and other non-specific - 2.4 %.  Read Full »


Dr. Parth R Goswami

Answer: Hi, Welcome to icliniq.com. According to the report attached (attachment removed to protect patient identity), the Mentzer index is not below 13. Usually, in thalassemia, it is below 13. Hb A2 (hemoglobin A2) level is raised, which is seen in beta thalassemia minor as well as in hemoglobin E hemogl...  Read Full »

Is my friend's beta thalassemia screening test normal?

Query: Hello doctor, My cousin of 30 years old got tested for beta thalassemia screening test. He got the result as hemoglobin A2 is 2.8 %, hemoglobin F is 0.2 %, hemoglobin C, D and S are not detected. Is this normal or has any complication? Please guide.  Read Full »


Dr. Prakash H. Muddegowda

Answer: Hi, Welcome to icliniq.com. Based on your query, my opinion is as follows: The beta thalassemia screening test appears to be normal. HbA2 levels (hemoglobin A2) are normally between 2-3.3% and HbF levels (fetal hemoglobin) are 0.1-1.2% for this age. Both are normal. The other hemoglobin type is HbA ...  Read Full »

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