Common "Hereditary Spherocytosis" queries answered by top doctors | iCliniq

Hereditary Spherocytosis

Hereditary spherocytosis is a genetic condition affecting the red blood cells, characterized by destruction of the red blood cells in the spleen, yellow discoloration of the skin, and enlargement of the spleen. The cause of the condition is a genetic defect that is transferred from parents to children. The diagnosis of hereditary spherocytosis is made on the basis of peripheral blood smear examination, red cell fragility test, etc. The treatment of the condition includes blood transfusion, folic acid supplements, and partial or complete removal of the spleen.

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How to manage hereditary spherocytosis?

Query: Hello doctor,I have been diagnosed with mild hereditary spherocytosis. My eyes are still yellow. Is it unlikely hematologist who diagnosed me three years ago was misdiagnosed? I do not doubt he knows his stuff. More about me getting worried. I lost weight a couple of months ago. I went very yellow i...  Read Full »


Dr. Singh Smrita

Answer: Hello, Welcome to icliniq.com. I have gone through your laboratory reports (attachment removed to protect patient identity) and they are consistent with the diagnosis made by your doctor. The yellowish tint of the eyes is due to increased bilirubin levels. This is due to the increased red blood ...  Read Full »

My liver readings are elevated. Does it indicate liver damage?

Query: Hello doctor,I am 29 years old with 180 cm tall and 62 kg weight. I was diagnosed with hereditary spherocytosis before five years, and my gallbladder was removed. Recently had an ultrasound to see the liver and spleen. I would have mildly elevated liver readings. Hematologist wanted to check that th...  Read Full »


Dr. Vivek Chail

Answer: Hello, Welcome to icliniq.com. Your spleen is enlarged in size (attachment removed to protect patient identity). The liver appears normal in size, and the echotexture looks normal. I would like to know which liver readings get elevated? Liver enzymes can get elevated when the hemolysis is not enti...  Read Full »

What is causing the jaundice of the sclera and itchy skin I am experiencing?

Query: Hello doctor, What is causing jaundice of sclera and itching on the skin that started about six weeks ago? My gall bladder has been removed, and the common bile duct is dilated to 8.4 mm. The MRI scan was unremarkable, as well as the ultrasound. I also have hereditary spherocytosis. Currently, I am ...  Read Full »


Dr. J. N. Naidu

Answer: Hello, Welcome to icliniq.com. It appears that hereditary spherocytosis is responsible for the problem. It results in an increased breakdown of RBC or red blood cells, which results in hemolytic anemia. Jaundice is due to hereditary spherocytosis, and jaundice is causing itching.  Read Full »

Are elevated bilirubin and blood in urine complications of hereditary spherocytosis?

Query: Hi doctor, I have hereditary spherocytosis with snapping scapula and spermatocele. Before few weeks, I took some blood tests. I had elevated levels of bilirubin and low WBC levels. Yesterday, I took a urine sample and found a large amount of blood in my urine. Is this serious? Can I have a blood di...  Read Full »


Dr. Penchilaprasad Kandikattu

Answer: Hi, Welcome to icliniq.com. Yes, it is a disorder that may cause an unstable RBC (red blood cells) membrane leading to produce spherical-shaped RBC. After passing through the spleen, it causes hemolysis. The common complications are anemia, jaundice, gall stones, folic acid deficiency, and aplasti...  Read Full »

I am pregnant with hereditary spherocytosis and abnormal blood test results. What should I do?

Query: Hello doctor, I am eight weeks pregnant. This is my first pregnancy, and I have nausea and constipation. Early pregnancy blood work showed an increased transferrin saturation, mild anemia, and higher B12 level in blood. I was diagnosed with hereditary spherocytosis a few years ago, so my spleen is m...  Read Full »


Dr. Mubashir Razzaq Khan

Answer: Hello, Welcome to icliniq.com. Thank you for your query. I read your query and understand your concern. You need to keep your vitamin B12, folic acid, pyridoxine, vitamin D, and iron within the upper limits of reference ranges. As hereditary spherocytosis is a high-utility state of the body due ...  Read Full »

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