How accurate is the herpes IgG blood test?
Patient's Query
Hi doctor,
I had a lump inside my lower lip. I got an excisional biopsy after four weeks of the lump being present, which came out negative for cancer. Also, the doctor said it was an inflamed minor salivary gland and nothing to worry about. I asked him about herpes, and he said no such thing was detected in a biopsy. I did a herpes IgG blood test after 14 weeks of the lump presenting, and it was negative. How sure can I be that it is not herpes?
Please help me.
Thanks.
Hi,
Welcome to icliniq.com
I have read your query and can understand your concern.
Swelling in the lower lips can be due to various causes such as salivary gland blockage, trauma, allergy, infection, and rarely cancers. Often, it is a matter of exclusion by investigations that help reach a diagnosis.
Accompanying symptoms, involving the rest of the face, neighbouring lymph nodes, and teeth conditions, are helpful to distinguish and properly diagnose lip enlargement. Also, abnormalities of the endocrine system ( glands such as the thyroid) or exocrine system ( salivary gland blockage) can be a cause as well.
Since the biopsy report is negative for cancer, it is positive for noncancerous causes.
As for oral herpes (simplex) infection, oral herpes simplex virus infection, there would be Initial redness, swelling, heat, or pain, or itching may develop in the area where the infection will erupt.
Painful, fluid-filled blisters may appear on the lips. The blisters will leak fluid and become sores. After about four to six days, the sores will start to crust over and heal. Herpes can be diagnosed in two ways: by detecting the presence of the virus in lesions or the antibodies in the blood.
In your case, you undertook antibody (IgG) detection in the blood, commonly positive 2 to 12 weeks after infection. Since you did this at four weeks and found negative, there appears to be no herpes simplex virus, although this is an indirect test.
Maybe you could get the direct test with the lesion, which the pathologist or microbiologist would perform under a microscope. We request that you kindly share the picture of the lesion (if possible with face and eyes covered), biopsy report, and IgG detection reports to better understand and advise further.
Reply to me if you have more concerns or questions.
I hope this information helps you.
Thank you.
Patient's Query
Hi doctor,
I do not have the lump anymore. They took it out during the biopsy, which was done after six weeks from the date the lump appeared. I have done a herpes IgG blood test after 14 weeks from the lump appeared, and it is negative.
Thank you.
Hi,
Welcome back to icliniq.com.
Thank you for your details. The signs and symptoms are not suggestive of herpes labialis. Negative IgG further adds evidence to the diagnosis. As the biopsy is negative for a cancerous lesion, there is no recurrence as well. All the above points point to a non-infective, non-cancerous pathology, possibly salivary gland outlet blockade. If the lesion reappears, please try to consult the surgeon for surgical management.
Thank you.
Patient's Query
Hi doctor,
I also did an IgG blood test at 18 weeks and 20 weeks, and both were negative.
Thank you.
Hi,
Welcome back to icliniq.com,
As you have covered the duration, there is no need to worry. Did you have any possible exposure making you susceptible to herpes labialis? Did you have any history of sexual exposure or kissing, or sharing utensils with an infected person? If not, then there is no reason to worry about herpes. Also, kindly share all the Herpes IgG reports.
Thank you.
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