TPO, or thyroid peroxidase, is an enzyme necessary for the production of thyroid hormone. High TPO levels indicate an autoimmune reaction against the thyroid gland, also known as autoimmune thyroiditis or Hashimoto's disease. Symptoms of high TPO levels may include fatigue, weight gain, hair loss, cold intolerance, and depression. High TPO levels can lead to hypothyroidism, a condition in which the thyroid gland doesn't produce enough thyroid hormones. A blood test can be used to determine TPO levels, and this is frequently done as part of a standard thyroid panel.
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