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How to manage a hypopigmented patch on the upper lip?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello Doctor,

For the past one and a half months, I noticed that a small portion of my upper lip is becoming slightly lighter-toned (whiter). It is not too white, but if I look carefully, I can understand that the pigmentation has lessened. Attached please find the photo.

I have pigmented lips, and I occasionally use lipstick. I apply lip balm often but not regularly, although I am not applying it to the upper lip now.

I have been taking Rexipra 5 for a year for anxiety issues. Please note that I experience facial sensations (as if something is flowing) and tight jaws due to my anxiety issues. I feel such sensations in my lips as well.

Please suggest any ointment to apply.

Kindly help.

Hello,

Welcome to icliniq.com.

I read your query and understood your concern.

I suggest you consider the following:

  1. Apply Tacroz (Tacrolimus) 0.1 percent ointment at night for three weeks (on the hypopigmented patch).

  2. Apply lip gel during the daytime.

  3. Apply lip serum in the evening for one month.

  4. Reduce exposure to irritants.

  5. Maintain proper hydration.

  6. Drink plenty of water.

  7. Use hydrating lip balm.

  8. If the lips are dry, apply a lip balm twice daily for one month.

  9. Avoid fragrance-based gels, creams, or cosmetics.

  10. Avoid scratching and rubbing.

  11. Avoid chronic friction.

  12. Avoid lip biting or lip licking, as it may cause hypopigmentation.

  13. Take Tablet Limcee (Vitamin C) 500 mg once a day after breakfast for 30 days.

  14. Take one Tablet Zincovit (multivitamin with zinc) 110 mg once a day after dinner for 30 days.

  15. Eat a diet rich in antioxidants, omega-3 fatty acids, vitamin A, vitamin C, and zinc.

  16. Reduce excessive use of cosmetics such as lipsticks.

A secondary cause could be contact allergens, such as a new toothpaste; irritation from mouthwash; exposure to an extreme environment; food allergies to foods such as nuts, pineapple, garlic, citrus fruits; certain medications; and dehydration. Do not worry. It will subside. Reduce exposure to irritants.

I hope that this answers your query.

Kindly follow up if you have more doubts.

Thank you.

Medically reviewed byiCliniq medical review team

Published At February 7, 2026
Reviewed AtFebruary 19, 2026

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