Knuckle hyperpigmentation occurs due to genetic causes. It often occurs in dark pigmentated people. Dark knuckles can also occur as a symptom of several health conditions. People affected with acanthosis nigrans, dermatosis, vitamin B12 deficiency, and Addison's disease are more prone to develop this skin condition. Knuckle hyperpigmentation is treated depending on the cause. It is usually treated by medication, doing lifestyle changes, and other therapies.
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