Liver Cirrhosis

Liver cirrhosis is late-stage fibrosis of the liver that occurs when scar tissue gradually replaces healthy liver tissue due to long-term alcohol abuse or infection. A variety of conditions or illnesses can lead to liver cirrhosis, such as alcohol abuse, nonalcoholic fatty liver disease, viral hepatitis, cystic fibrosis, Wilson's disease, and alpha-1 antitrypsin deficiency. People with liver cirrhosis may have appetite loss, weakness, nausea and vomiting, weight loss, itching, swelling in the legs, feet, ankles, low sex drive, easy bleeding and bruising, and ascites. Treatment involves avoiding alcohol, medications to control hepatitis and other symptoms of liver cirrhosis.

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My father is taking tablets Midodrine for liver cirrhosis and is experiencing high blood pressure now. Why?

Query: Hi doctor, My father is suffering from non-alcoholic liver cirrhosis. So a doctor prescribed taking tablet Midodrine (Midodrine Hydrochloride) 2.5 mg for controlling ascites fluid accumulation. Initially, it was prescribed to take four tablets a day, and my dad suffered from high blood pressure. Lat...  Read Full »


Dr. Ajeet Kumar Lohana

Answer: Hello,Welcome to icliniq.com. I can understand your concern.The tablet Midodrine (Midodrine Hydrochloride) is safe and can be used in patients with high blood pressure. In fact, this medication is a diuretic, which increases urine output, and thus decreases blood pressure.I suggest you (consult with...  Read Full »

My AST is 13, and my ALT is 6. Do I need further testing?

Query: Hello doctor, I recently had a blood draw at home by a visiting nurse for a life insurance application. AST (aspartate aminotransferase)/ALT (alanine aminotransferase) ratio came back high at 2.2. However, all other levels of my blood report are normal. AST is 13, and ALT is 6, so neither level is e...  Read Full »


Dr. Utkarsh Sharma

Answer: Hello, Welcome to icliniq.com. I understand your concern and will help you regarding it. ALT/AST ratio can provide information about cirrhosis/liver damage but in proper context. These results are often interpreted in association with ultrasonography and other liver function tests. In your ...  Read Full »

Kindly review my mother's liver function report, and give your opinion on the need for a liver transplant.

Query: Hello doctor, My 57-year-old mother was diagnosed with a hepatitis B infection two years, and she is under regular medications. We performed a liver function test last year, which revealed that her liver was in good shape. However, she was recently diagnosed with liver cirrhosis, caused by the ...  Read Full »


Dr. Ajeet Kumar Lohana

Answer: Hello, Welcome you to icliniq.com. Unfortunately, the report is not satisfactory. The CT (computed tomography) scan and the raised alpha protein suggest that she has a tumor in the liver (attachments removed to protect the patient’s identity). Although the abdominal MRI (magnetic reso...  Read Full »

Are alcohol and tablet Tylenol the reason for my elevated liver enzymes?

Query: Hello doctor, I am a 37-year-old female. I had a VSG surgery with gall bladder removal six months ago. My ALT, AST, and ALP were fine and within the normal range during the time of surgery. But my recent blood reports show abnormal values of AST, ALT, and ALP. I have been drinking alcohol every w...  Read Full »


Dr. Penchilaprasad Kandikattu

Answer: Hello, Welcome to icliniq.com. I have gone through all your investigation reports (attachments removed to protect the patient’s identity). Elevated SGOT (serum glutamic-oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) is not a criteria for liver cirrhosis. Chances...  Read Full »

Are my symptoms and elevated liver enzymes due to liver cirrhosis?

Query: Hi doctor, I am a 26-year-old male with a weight of 184 kilograms and a height of five feet seven inches. I am experiencing some weird symptoms for the past three months. I am a recovering binge eating addict. I use to eat fast food two to three times a day usually with meal size after work. Late...  Read Full »


Dr. Ajeet Kumar Lohana

Answer: Hi, Welcome to icliniq.com. Your weight is slightly higher. Your body mass index is 27.2. Ideally, it should be less than 25. BMI is proportionate of your weight according to your height. So, you have a possibility of having fatty liver disease due to deranged liver function tests. Your FIB-4 (fib...  Read Full »

Based on the reports, please suggest the cause of the sudden changes in the liver.

Query: Hi doctor, I am a 53-year-old male. Before a year, I had painless jaundice. My MRCP report showed a mass on the head of the pancreas. My endoscopic USG showed a stricture in CBD and so a stent was inserted. My bilirubin came down and Whipple procedure was planned. As my TSH was more than 20 mIU/L...  Read Full »


Dr. Arbab Muhammad Kashif Khan

Answer: Hi, Welcome to icliniq.com. You can have two possibilities. You can have long biliary obstruction due to CBD (common bile duct) compression. It can lead to cirrhosis causing biliary cirrhosis. Any abdominal infection can cause portal vein thrombosis. It leads to have a nodular texture in the liver...  Read Full »

Can liver failure cause blood in urine and weakness?

Query: Hi doctor,My 73 years old dad is becoming weak day by day, and he is 70 kg by weight and 5.2 inches by height. We consulted the doctor, who told us the urine contains blood, although it is not visible looking at urine. His leg was also swelling, and on medication, it became fine. He also added, it m...  Read Full »


Dr. Ajeet Kumar Lohana

Answer: Hello, Welcome to icliniq.com. I can understand you must be very upset about your father. The history you provided provides a little clue of what exactly he is suffering with. Non-visible blood in urine is called microscopic hematuria. Some liver conditions can cause this problem, such as hepatiti...  Read Full »

May I know whether cirrhosis of liver become worse by continuous drinking of alcohol?

Query: During Covid i drank excessively. And was a regular drinker before. I had a bleeding episode before 5 months. My alt was 130 and i had an untra sound that was suspicious for early stage chirrosis. Now i haven't drank in 5 months. All my numbers are normal. Alt 30's i did have an endoscope that sho...  Read Full »


Dr. Ajeet Kumar Lohana

Answer: Hello welcome you to icliniq. Actually once cirrhosis is developed l, it is irreversible in nature. Meaning avoiding alcohol would prevent disease from progressing but never reset the cirrhosis back to normal liver tissue. Any further intake of alcohol however, would worsen the cirrhosis and thats...  Read Full »

What test should I undergo to rule out liver cirrhosis?

Query: Hello doctor, I am very concerned about my liver. I have a history of alcohol use of approximately two to four beers per night, approximately five nights per week for nearly 20 years. I am under total abstinence for the past one year. My symptoms are aching pain in the back on the right side under...  Read Full »


Dr. Sandeep V Nair

Answer: Hi, Welcome to icliniq.com. Given the amount of alcohol that you are taking and the duration you have taken, it is likely that you can develop cirrhosis. But the development of cirrhosis is a gradual process, and it takes a long time before it is evident on the tests. Fibroscan is a useful modali...  Read Full »

Can NASH progress to cirrhosis due to drastic weight loss?

Query: I was diagnosed with NASH 6 years ago but not given any proper advice except lose weight. A Fibroscan reading of 4.3 (3 years back) and I was not told anything just given the paper readout. Last year, my Fibroscan was 6.6. And I was told “live your life” don’t worry. 2 months ...  Read Full »


Dr. Ajeet Kumar Lohana

Answer: Hello. I welcome you to icliniq. The diagnosis of NASH means there was presence of inflammation in the liver. Which should be evident on ALT more than 1.5x normal or AST more than 1.5x normal, while excluding other etiologies and in absence of significant active alcohol intake. The Significant al...  Read Full »

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