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What is the best immunosuppressant for lupus nephritis?

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Patient's Query

Hello doctor,

I was diagnosed with lupus nephritis last year, and I feel like my symptoms are getting worse. My legs and face are more swollen. I am feeling exhausted all the time, and my urine has been very foamy. My last lab results showed that my kidney function is not looking great, there is more protein in my urine, and my creatinine levels are creeping up. I am on Prednisone and Mycophenolate, but should we be making any changes? What else can I do to help prevent my kidneys from getting worse?

Please help.

Thank you.

Answered by Dr. Sally Attalah

Education:

BDS

Professional Bio:

Dr. Sally Attalah is an experienced Dental Surgeon with a Bachelor of Dental Surgery earned in 2007, followed by her internship in 2008. She has been an affiliate member of the American Dental Association since 2015, reflecting her commitment to maintaining global standards in dental care. Dr. Sally is dedicated to providing high-quality oral healthcare with a patient-focused approach.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I understand your concern.

Lupus nephritis, kidney inflammation caused by systemic lupus erythematosus (autoimmune diseases), is often managed with immunosuppressants, chemotherapy, and corticosteroids, also known as steroids, that suppress your immune system, antimalarial drugs, and blood pressure medicines to prevent damage to your kidneys.

Medicines to treat lupus nephritis might include:

  1. Steroids, such as Prednisone.

  2. Cyclosporine.

  3. Voclosporin.

  4. Tacrolimus.

  5. Cyclophosphamide.

  6. Azathioprine.

  7. Mycophenolate.

  8. Rituximab.

The following play a crucial role in preventing complications:

  1. Exercising regularly.
  2. Following a low-sodium and low-cholesterol diet.
  3. Staying hydrated.
  4. Avoiding alcohol and smoking.

I hope this helps.

Kindly follow up if you have more concerns.

Thank you.

Medically reviewed by iCliniq medical review team
Published At May 31, 2025
Reviewed At June 13, 2025

Education:

BDS

Professional Bio:

Dr. Sally Attalah is an experienced Dental Surgeon with a Bachelor of Dental Surgery earned in 2007, followed by her internship in 2008. She has been an affiliate member of the American Dental Association since 2015, reflecting her commitment to maintaining global standards in dental care. Dr. Sally is dedicated to providing high-quality oral healthcare with a patient-focused approach.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

BDS

Professional Bio:

Dr. Sally Attalah is an experienced Dental Surgeon with a Bachelor of Dental Surgery earned in 2007, followed by her internship in 2008. She has been an affiliate member of the American Dental Association since 2015, reflecting her commitment to maintaining global standards in dental care. Dr. Sally is dedicated to providing high-quality oral healthcare with a patient-focused approach.

This doctor is not available for online consultations on the platform anymore.

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