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What causes irregular periods despite stopping progesterone?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have been off Depo for almost two years. My periods are still messed up, and I cannot get pregnant.

Please help.

Answered by Dr. Sofia John

Hello,

Welcome to icliniq.com.

I understand your concern.

After stopping Depo-Provera (Medroxyprogesterone acetate), periods are likely to return. However, your infertility may be due to some other factors, like:

  1. Obesity: Your high body fat percentage may alter your hormones and prevent ovulation.

  2. Polycystic ovarian syndrome (PCOD): You may be having anovulatory cycles because of your PCOD; therefore, we need to investigate further using some blood tests and an ultrasound.

  3. Other hormonal issues, like thyroid and prolactin.

  4. Stress and quality of life, including a sedentary lifestyle.

My advice:

  1. Visit a gynecologist and get your prenatal checkup done: this includes testing of routine blood tests like complete blood count, thyroid profile, serum levels of prolactin, estrogen, and progesterone, and testosterone levels to rule out PCOS.

  2. You can use ovulation kits to track your ovulation time and know if you are ovulating.

  3. Lifestyle changes:

  • Diet and weight reduction using a calorie-deficient diet. Monitor your calorie intake and focus on taking a high-protein, high-fiber diet, including more cruciferous vegetables.

  • Introduce brisk walking and strength training five times a week into your daily habits, and focus on reducing your weight to an ideal BMI (body mass index) since you are currently obese according to your BMI.

  • Avoid eating junk foods and high-calorie foods like soda, sugars, chocolates, and cheese.

  1. Consider getting a fertility checkup for both you and your partner.

I hope this has helped you.

Please feel free to reach out to me again if you have further queries.

Thank you.

Answered byDr. Sofia John

Medically reviewed byiCliniq medical review team

Published At September 6, 2025
Reviewed AtSeptember 8, 2025

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