Methotrexate

Methotrexate is an immunosuppressant and chemotherapeutic drug, which is used to treat cancer (leukemia, breast cancer, lymphoma, and lung cancer) and various autoimmune diseases (psoriasis, Crohn's disease, and rheumatoid arthritis). It can also be used for ectopic pregnancies and medical abortions. This drug prevents the growth of certain cells that reproduce quickly in the body, for example, cancer and skin cells.

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What can be the reason for swelling and pain in my right wrist?

Query: Hi doctor, I am a 27 year old female, and I was diagnosed with RA late last year. It has been persistent in my wrists this year. I was told to take Zycel 200 mg, but I feel something else could be wrong, as the pain and swelling are only in the wrists, more in the right hand. In my country, we do n...  Read Full »


Dr. Naval Mendiratta

Answer: Hi, Welcome to icliniq.com. If you have been diagnosed with rheumatoid arthritis, then it is possible the swelling in the wrists is due to it. And moreover, we need to step up the treatment as only Zycel (Celecoxib) 200 mg is not enough to control it. It would be better if one could add Methotrexate...  Read Full »

Can I take Xelijanz for rheumatoid arthritis?

Query: Hi doctor, I was diagnosed with rheumatoid arthritis, and my doctor advised to take Xeljanz, as it has no side effects. Is it true? It is very expensive. I want to take a second opinion on the medicine. How safe is it to take?  Read Full »


Dr. Divya Agarwal

Answer: Hi, Welcome to icliniq.com. Yes, it is a very good option for rheumatoid arthritis. However, every medicine has its side effects. It is recommended to start with the time-tested DMARDs (disease-modifying antirheumatic drugs) like Methotrexate and sometimes, even combination of DMARDs. If they fail...  Read Full »

Will Methotrexate cause more hair fall when used for alopecia areata?

Query: Hi doctor,I am a 31-year-old female. Currently, I have alopecia areata. It got flared up due to my current stress situation. I am looking for a medication to cure it. I heard about Dexamethasone and Methotrexate for treating it. My dermatologist advised me to take Methotrexate. I am concerned about ...  Read Full »


Dr. Deepti Shukla

Answer: Hi, Welcome to icliniq.com. Alopecia areata is a chronic recurrent condition that occurs due to a genetic component. Due to its genetic component, it has a tendency to recur again and again. Both Dexamethasone and Methotrexate are good options. Taking Methotrexate is better as it causes fewer ...  Read Full »

How long will a joint swelling take to cause permanent joint damage in psoriatic polyarthritis?

Query: Hello doctor, Patient is 10 years old with psoriasis polyarthritis. Received Methotrexate, and Enbrel for three years. As in medical remission, it was decided ten months ago to stop Methotrexate and continue only with Enbrel. Three months later started having infections and paradoxical reaction to ...  Read Full »


Dr. Naval Mendiratta

Answer: Hello, Welcome to icliniq.com. I have gone through your history. Well, it seems like you developed a reaction to Enbrel which is quite common as it does flare psoriasis in some patients. Pertaining to your queries: Since you have mentioned only one ankle is swollen, it is not justified taking su...  Read Full »

Kindly examine my father's biopsy report and suggest a treatment plan.

Query: Hi doctor, I am writing on behalf of my father, who is 64 years old. He is a diabetic patient, but his diabetes is completely under control. A few weeks before, he found some blood coming out along with his urine. He consulted a few doctors and went under some tests. He was found to have a tumor in ...  Read Full »


Dr. Bharat Patodiya

Answer: Hi, Welcome to icliniq.com. As the biopsy is showing high grade tumor and involves muscularis propria, this makes a T2 stage. The latest guideline suggests a Cisplatin based chemotherapy followed by radical cystectomy (bladder removal). Pelvic node dissection should be done even if CT scan did no...  Read Full »

Is there any alternate for steroid drugs?

Query: Hello doctor, My son is taking steroids for the past six months, and he is facing a lot of issues concerning the side effects of the medicines. Please have a look at the attached details of the problems faced by him till date. You had also told us that the medication he is taking would have side ef...  Read Full »


Dr. Sagar Ramesh Makode

Answer: Hello, Welcome to icliniq.com. Firstly, most of these side effects are attributed to steroids, which were going on in high doses for the initial few weeks. Now the dose is significantly reduced by his treating doctor to 6 mg only, so most of his side effects will gradually subside. Next, regar...  Read Full »

What can be done for my skin disease?

Query: Hello doctor, I had red, scaly patches all over my body. I consulted a doctor and he said it as Pityriasis rosea. I took treatment for a month, but I guess they are enlarged. Now, I have completely stopped medicines. I took Averzine 25, L-Cet 5 mg, applied Propynate, Clobivax and Galderma. Another d...  Read Full »


Dr. Sampada Avinash Thakare

Answer: Hi, Welcome to icliniq.com. I have gone through your investigation reports and they are normal (attachment removed to protect patient identity). I have seen your images and it is psoriasis only. Yes, a skin biopsy should be done to have documentation for the future. It is a very small procedure...  Read Full »

What is the proper medicaion for severe RA symptoms?

Query: Hello doctor, My mother is 65 years old. She is RA positive for the last 25 years. Currently, she takes HCQs, Methotrexate, pain killer, and Rantac. At present, she has pain, nodules in hand, and turned feet. Please suggest proper medication. Her LFT and KFT are normal.  Read Full »


Dr. Naval Mendiratta

Answer: Hi, Welcome to icliniq.com. I have gone through your query. But the report images could not reveal anything. (attachment removed to protect patient identity). I would like to ask you a few more queries before suggesting the medicine as any new DMARD (disease-modifying antirheumatic drug) starte...  Read Full »

Will ectopic pregnancy terminates on its own as miscarriage?

Query: Hello doctor, Can an ectopic pregnancy be detected on a transvaginal or simple abdominal ultrasound, if I am in two to three weeks of pregnancy? What are the chances that an ectopic pregnancy miscarries spontaneously? In case of rupture to the fallopian tube in the ectopic pregnancy, does the pregn...  Read Full »


Dr. Nawajsharif G Mujawar

Answer: Hi, Welcome to icliniq.com. Transvaginal ultrasound can detect ectopic as early as two weeks, much before TAS (transabdominal sonography). Ectopic pregnancy always terminates as miscarriage, but inside the abdomen with profuse bleeding intraabdominally that can be life threatening. Pregnancy ends...  Read Full »

Can UCTD and MCTD occur together?

Query: Hello doctor, I am currently struggling with a flare that is just not getting better. My symptoms started three years ago. At that time my ANA was high positive, lupus anticoagulant positive, but nothing else specific. My symptoms are joint pain, swelling, severe fatigue, severe hand swelling, sev...  Read Full »


Dr. Naval Mendiratta

Answer: Hello, Welcome to icliniq.com. I believe your diagnosis is Overlap syndrome, scleroderma with myositis overlap. Your symptoms do not fit into one connective tissue disease. It is probably overlap of two diseases going on. Lupus I will not be too sure, as you do not specify symptoms pertaining to i...  Read Full »

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