Common "Methotrexate" queries answered by top doctors | iCliniq


Methotrexate is an immunosuppressant and chemotherapeutic drug, which is used to treat cancer (leukemia, breast cancer, lymphoma, and lung cancer) and various autoimmune diseases (psoriasis, Crohn's disease, and rheumatoid arthritis). It can also be used for ectopic pregnancies and medical abortions. This drug prevents the growth of certain cells that reproduce quickly in the body, for example, cancer and skin cells.

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Can I have a side effect due to Methotrexate for arthritis?

Query: Hi doctor,I was advised to take Methotrexate 15 mg. I am taking it for nine weeks. I get a lot of joint pain, especially in the shoulders, elbows, and fingers. I have some skin issues. My doctor told me it was psoriatic arthritis. My doctor has advised me to use Enstilar spray and Eukroma cream. Is ...  Read Full »

Dr. Reinhard Spyra

Answer: Hi, Welcome to Methotrexate is a well-known drug used for arthritis. If you have regular control, then you can manage its side effects. Their side effects are treatable. But arthritis damages joints and it is irreversible. Some people split their dosage or take it in the evening. If y...  Read Full »

I am suffering from ankylosing spondylitis. Kindly help.

Query: Hello doctor,I am suffering from ankylosing spondylitis from two years. Can you please tell me whether there are chances to slow the disease progression and how?  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to There are four modes of therapy for ankylosing spondylitis. NSAID (non steroidal anti inflammatory drugs) group, steroid, disease-modifying anti-rheumatic drugs such as Methotrexate, TNF blocker like Adalimumab, physiotherapy also should be done, also avoid smoking, m...  Read Full »

Can Methotrexate lower my hCG levels in ectopic pregnancy?

Query: Hello doctor, I have a query on ectopic pregnancy. My wife is having one and her beta hCG levels were 125.25 mIU/ml after taking her first shot of Methotrexate. Yesterday, she got her second shot and her beta hCG levels today were 141. I wanted to know how much time Methotrexate takes to low down th...  Read Full »

Dr. Sravanthi Nuthalapati

Answer: Hello, Welcome to I hope you had taken the Methotrexate dose under supervision only. The usual protocol is to check for a repeat beta hCG on the fourth day of taking Methotrexate. Early testing may cause undue anxiety and panic as it takes some time for the levels to come down. Moreov...  Read Full »

How long will a joint swelling take to cause permanent joint damage in psoriatic polyarthritis?

Query: Hello doctor,The patient is 10 years old with psoriasis polyarthritis and received Methotrexate, and Enbrel for three years. As in medical remission, it was decided ten months ago to stop Methotrexate and continue only with Enbrel. Three months later started having infections and a paradoxical react...  Read Full »

Dr. Naval Mendiratta

Answer: Hello,Welcome to have gone through your history. Well, it seems like you developed a reaction to Enbrel which is quite common as it does flare psoriasis in some patients. Pertaining to your queries: Since you have mentioned only one ankle is swollen, it is not justified to take such a ...  Read Full »

My father has a tumor in his urinary bladder. Please help.

Query: Hi doctor, I am writing on behalf of my father, who is 64 years old. He is a diabetic patient, but his diabetes is completely under control. A few weeks before, he found some blood coming out along with his urine. He consulted a few doctors and went under some tests. He was found to have a tumor in ...  Read Full »

Dr. Bharat Patodiya

Answer: Hi, Welcome to As the biopsy is showing high grade tumor and involves muscularis propria, this makes a T2 stage. The latest guideline suggests a Cisplatin based chemotherapy followed by radical cystectomy (bladder removal).Pelvic node dissection should be done even if CT scan did not...  Read Full »

I am diagnosed with scleroderma. Please help.

Query: Hi doctor, I traveled to a different country to get more in depth testing of multiple health problems. I was diagnosed with the start of scleroderma, because of my gastrointestinal symptoms, idiopathic angioedema, thickened skin, weird blood vessels (tiny red tree-like veins), family history of scle...  Read Full »

Dr. Bharat Patodiya

Answer: Hi, Welcome to Considering your symptoms, scleroderma (an autoimmune disorder characterized by skin hardening) could be a possibility. To assess further, it's essential to determine the pattern of sclerosis, which typically starts from the hands and spreads to the main trunk. Additiona...  Read Full »

I am 4 weeks pregnant. Can I continue taking Methotrexate?

Query: Hello doctor, I am approximately four weeks pregnant based on the date of conception. I have rheumatoid arthritis and take Methotrexate 10 mg a week, along with Folic acid 10 mg. I stopped taking Methotrexate as soon as I found out about the pregnancy, which was one week ago. So, since conception, ...  Read Full »

Dr. Chibitam Hope Obia

Answer: Hello, Welcome to I have read your query, and I can understand your concern. You do not need to worry about your exposure to Methotrexate during your four-week pregnancy. As long as it is not an overdose, I do not think it may affect your pregnancy. To be sure, please kindly undergo ...  Read Full »

Will ectopic pregnancy terminate on its own as miscarriage?

Query: Hello doctor, Can an ectopic pregnancy be detected on a transvaginal or simple abdominal ultrasound, if I am in two to three weeks of pregnancy? What are the chances that an ectopic pregnancy miscarries spontaneously? In case of rupture to the fallopian tube in the ectopic pregnancy, does the pregn...  Read Full »

Dr. Mujawar Nawajsharif Gaibiso

Answer: Hi, Welcome to Transvaginal ultrasound can detect ectopic as early as two weeks, much before TAS (transabdominal sonography). Ectopic pregnancy always terminates as miscarriage, but inside the abdomen with profuse bleeding intraabdominally that can be life threatening. Pregnancy ends ...  Read Full »

My mother has rheumatoid arthritis. Can she take Glucosamine?

Query: Hello doctor, My mother has primary symptoms of rheumatoid arthritis. She takes Methotrexate 10 mg weekly and for her heart, she takes Nebicard 5 mg and Caat 20 mg. She has no flaring of her symptoms but random mild joint pain occasionally. I would like to know is she in remission? How do you define...  Read Full »

Dr. Sharoff Lokesh Mohan

Answer: Hello, Welcome to Yes, she is in remission. It is defined as clinically or less joint pain and or swelling with no morning stiffness. I suggest she can take Glucosamine. There is no interaction with the other drugs that she is taking, Common side effects of Glucosamine are diarrhea, c...  Read Full »

I have chronic lupus pain. Please help.

Query: Hello doctor, I am experiencing chronic lupus pain every day which is debilitating and unpredictable and is making day-to-day tasks unbearable. I am always fatigued and tend to take multiple breaks throughout the day. Currently, I am taking Methotrexate and Endone. Kindly help.   Read Full »

Dr. Albana Greca

Answer: Hello, Welcome to You now have exclusive access to expert medical opinion. I am sorry to hear that you are experiencing chronic pain and fatigue due to lupus. Lupus is an autoimmune disease that can cause inflammation throughout the body, leading to a range of symptoms, including join...  Read Full »

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