Methotrexate

Methotrexate is an immunosuppressant and chemotherapeutic drug, which is used to treat cancer (leukemia, breast cancer, lymphoma, and lung cancer) and various autoimmune diseases (psoriasis, Crohn's disease, and rheumatoid arthritis). It can also be used for ectopic pregnancies and medical abortions. This drug prevents the growth of certain cells that reproduce quickly in the body, for example, cancer and skin cells.

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All the answers published in this website are written by Verified medical doctors, therapists and health experts. The Content has been moderated by iCliniq medical review team before publication. Post your medical clarifications on iCliniq by choosing the right specialty and get them answered. Your medical queries will be answered 24/7 by top doctors from iCliniq.

Kindly examine my father's biopsy report and suggest a treatment plan.

Query: Hi doctor, I am writing on behalf of my father, who is 64 years old. He is a diabetic patient, but his diabetes is completely under control. A few weeks before, he found some blood coming out along with his urine. He consulted a few doctors and went under some tests. He was found to have a tumor in ...  Read Full »


Dr. Bharat Patodiya

Family Physician, General Medicine Physician, General Practitioner, Internal Medicine Physician, Medical Oncologist

Answer: Hi, Welcome to icliniq.com. As the biopsy is showing high grade tumor and involves muscularis propria, this makes a T2 stage. The latest guideline suggests a Cisplatin based chemotherapy followed by radical cystectomy (bladder removal). Pelvic node dissection should be done even if CT scan did no...  Read Full »

Can I have a side effect due to Methotrexate taken for arthritis?

Query: Hi I was prescribed methotrexate 15mg a week I am on my ninth week. Is this a safe medication? I regularly done blood tests? I used to get a lot of joint pain especially in shoulder elbow and finger. I also got skin issues so my doctor said it will be psoriatic arthritis? My dermatologist has giv...  Read Full »


Dr. Reinhard Spyra

Rheumatologist

Answer: Hello Welcome to icliniq. I'm happy to answer your query with a background of 40 years in Rheumatology. Please be aware that this is for information and doesn't replace the privileged patient-doctor relationship. Methotrexate, the drug is used worldwide, very well known since half a century for ar...  Read Full »

Is there any alternate for steroid drugs?

Query: Hello doctor, My son is taking steroids for the past six months, and he is facing a lot of issues concerning the side effects of the medicines. Please have a look at the attached details of the problems faced by him till date. You had also told us that the medication he is taking would have side ef...  Read Full »


Dr. Sagar Ramesh Makode

Cardiologist, General Medicine Physician, Internal Medicine Physician, Family Physician, General Practitioner

Answer: Hello, Welcome to icliniq.com. Firstly, most of these side effects are attributed to steroids, which were going on in high doses for the initial few weeks. Now the dose is significantly reduced by his treating doctor to 6 mg only, so most of his side effects will gradually subside. Next, regar...  Read Full »

Will Methotrexate cause more hair fall when used for alopecia areata?

Query: I currently have alopecia areata that has flared up due to the current stress of the situation. I'm looking at starting a medication to see if it can help. Two medications have been discussed dexamehtasone and methotrexate. Each would be a low doese (1-2 days/week) for 3 months. My dermatologist...  Read Full »


Dr. Deepti Shukla

Dermatologist, Venereologist

Answer: Hello, Don't worry I'll help you with your concern. I understand alopecia areata can be really stressful. Alopecia areata is chronic recurrent condition due to genetic component. Because of genetic condition, it's has tendency to recur again and again. Both methotrexate and dexamethasone are good ...  Read Full »

What can be done for my skin disease?

Query: Hello doctor, I had red, scaly patches all over my body. I consulted a doctor and he said it as Pityriasis rosea. I took treatment for a month, but I guess they are enlarged. Now, I have completely stopped medicines. I took Averzine 25, L-Cet 5 mg, applied Propynate, Clobivax and Galderma. Another d...  Read Full »


Dr. Sampada Avinash Thakare

Cosmetologist, Dermatologist, Venereologist

Answer: Hi, Welcome to icliniq.com. I have gone through your investigation reports and they are normal (attachment removed to protect patient identity). I have seen your images and it is psoriasis only. Yes, a skin biopsy should be done to have documentation for the future. It is a very small procedure...  Read Full »

What is the proper medicaion for severe RA symptoms?

Query: Hello doctor, My mother is 65 years old. She is RA positive for the last 25 years. Currently, she takes HCQs, Methotrexate, pain killer, and Rantac. At present, she has pain, nodules in hand, and turned feet. Please suggest proper medication. Her LFT and KFT are normal.  Read Full »


Dr. Naval Mendiratta

Rheumatologist

Answer: Hi, Welcome to icliniq.com. I have gone through your query. But the report images could not reveal anything. (attachment removed to protect patient identity). I would like to ask you a few more queries before suggesting the medicine as any new DMARD (disease-modifying antirheumatic drug) starte...  Read Full »

Will ectopic pregnancy terminates on its own as miscarriage?

Query: Hello doctor, Can an ectopic pregnancy be detected on a transvaginal or simple abdominal ultrasound, if I am in two to three weeks of pregnancy? What are the chances that an ectopic pregnancy miscarries spontaneously? In case of rupture to the fallopian tube in the ectopic pregnancy, does the pregn...  Read Full »


Dr. Nawajsharif G Mujawar

Obstetrician And Gynaecologist

Answer: Hi, Welcome to icliniq.com. Transvaginal ultrasound can detect ectopic as early as two weeks, much before TAS (transabdominal sonography). Ectopic pregnancy always terminates as miscarriage, but inside the abdomen with profuse bleeding intraabdominally that can be life threatening. Pregnancy ends...  Read Full »

Can UCTD and MCTD occur together?

Query: Hello doctor, I am currently struggling with a flare that is just not getting better. My symptoms started three years ago. At that time my ANA was high positive, lupus anticoagulant positive, but nothing else specific. My symptoms are joint pain, swelling, severe fatigue, severe hand swelling, sev...  Read Full »


Dr. Naval Mendiratta

Rheumatologist

Answer: Hello, Welcome to icliniq.com. I believe your diagnosis is Overlap syndrome, scleroderma with myositis overlap. Your symptoms do not fit into one connective tissue disease. It is probably overlap of two diseases going on. Lupus I will not be too sure, as you do not specify symptoms pertaining to i...  Read Full »

How long will a joint swelling take to cause permanent joint damage in psoriatic polyarthritis?

Query: Hello doctor, Patient is 10 years old with psoriasis polyarthritis. Received Methotrexate, and Enbrel for three years. As in medical remission, it was decided ten months ago to stop Methotrexate and continue only with Enbrel. Three months later started having infections and paradoxical reaction to ...  Read Full »


Dr. Naval Mendiratta

Rheumatologist

Answer: Hello, Welcome to icliniq.com. I have gone through your history. Well, it seems like you developed a reaction to Enbrel which is quite common as it does flare psoriasis in some patients. Pertaining to your queries: Since you have mentioned only one ankle is swollen, it is not justified taking su...  Read Full »

Why is there sudden worsening of rheumatoid arthritis even on medication?

Query: Hello doctor, I am 26 years old and diagnosed with rheumatoid arthritis when I was 23. Since then I have been on 15 mg of Methotrexate and Hydroxychloroquine. Since I have been on medication, I hardly have no symptoms, but recently arthritis seems to be flaring up for three weeks now. I have pain i...  Read Full »


Dr. Naval Mendiratta

Rheumatologist

Answer: Hello, Welcome to icliniq.com. Well, it is a possibility that Methotrexate dose is not sufficient enough to stop the disease. 15 mg is the dose we use for starting and we normally go higher up. In my experience, 15 mg normally proves inefficient in the long run. But since your disease is flarin...  Read Full »

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Disclaimer: All health Q&As published on this website are not intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek the advice from your physician or other qualified health-care providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.