Methotrexate

Methotrexate is an immunosuppressant and chemotherapeutic drug, which is used to treat cancer (leukemia, breast cancer, lymphoma, and lung cancer) and various autoimmune diseases (psoriasis, Crohn's disease, and rheumatoid arthritis). It can also be used for ectopic pregnancies and medical abortions. This drug prevents the growth of certain cells that reproduce quickly in the body, for example, cancer and skin cells.

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All the answers published in this website are written by verified medical doctors, therapists and health experts. The Content has been moderated by iCliniq medical review team before publication. Post your medical clarifications on iCliniq by choosing the right specialty and get them answered. Your medical queries will be answered 24/7 by top doctors from iCliniq.

What can be the reason for swelling and pain in my right wrist?

Query: Hi doctor, I am a 27 year old¬†female, and I was diagnosed with RA late last year. It has been persistent in my wrists this year. I was told to take Zycel 200 mg, but I feel something else could be wrong, as the pain and swelling are only in the wrists, more in the right hand. In my country, we do n...  Read Full »


Dr. Naval Mendiratta

Answer: Hi, Welcome to icliniq.com. If you have been diagnosed with rheumatoid arthritis, then it is possible the swelling in the wrists is due to it. And moreover, we need to step up the treatment as only Zycel (Celecoxib) 200 mg is not enough to control it. It would be better if one could add M...  Read Full »

What can be done to slow the disease progression in ankylosing spondylitis?

Query: Hello doctor,I am suffering from ankylosing spondylitis from two years. Can you please tell me whether there are chances to slow the disease progression and how?  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. There are four modes of therapy for ankylosing spondylitis. NSAID group. Steroid. Disease-modifying anti-rheumatic drugs such as Methotrexate. TNF blocker like Adalimumab. Physiotherapy also should be done. Avoid smoking. Maintain good posture. If inflammat...  Read Full »

Can UCTD and MCTD occur together?

Query: Hello doctor, I am currently struggling with a flare that is just not getting better. My symptoms started three years ago. At that time my ANA was high positive, lupus anticoagulant positive, but nothing else specific. My symptoms are joint pain, swelling, severe fatigue, severe hand swelling, sev...  Read Full »


Dr. Naval Mendiratta

Answer: Hello, Welcome to icliniq.com. I believe your diagnosis is Overlap syndrome, scleroderma with myositis overlap. Your symptoms do not fit into one connective tissue disease. It is probably overlap of two diseases going on. Lupus I will not be too sure, as you do not specify symptoms pertaining to i...  Read Full »

Kindly examine my father's biopsy report and suggest a treatment plan.

Query: Hi doctor, I am writing on behalf of my father, who is 64 years old. He is a diabetic patient, but his diabetes is completely under control. A few weeks before, he found some blood coming out along with his urine. He consulted a few doctors and went under some tests. He was found to have a tumor in ...  Read Full »


Dr. Bharat Patodiya

Answer: Hi, Welcome to icliniq.com. As the biopsy is showing high grade tumor and involves muscularis propria, this makes a T2 stage. The latest guideline suggests a Cisplatin based chemotherapy followed by radical cystectomy (bladder removal).Pelvic node dissection should be done even if CT scan did not...  Read Full »

Which foods are beneficial in arthritis?

Query: Hello doctor, My mother is suffering from arthritis. Is cow milk harmful to consume in her case (she drinks it daily)? Which foods are very beneficial for this disease or diet plan to remove it from the body as early as possible? Please reply. I need your help.  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. I have seen your reports (attachment removed to protect patient identity). Your RA factor is positive. So, for confirming rheumatoid arthritis, anti-CCP investigation can be done. Local part X-ray also needs to be done. Spinach, beet juice, and green leafy vegetabl...  Read Full »

I have ankle and calf muscle pain. Could it be RA?

Query: Hello doctor, I am a 38-year-old male, suffering from RA from the last two years and recently started the treatment with an orthopedic doctor for AVN of the hip. I have been told by my orthopedician at icliniq to consult a rheumatologist for my ankle and calf muscle pain, and for my RA medication an...  Read Full »


Dr. Srivastava Durgesh

Answer: Hello, Welcome to icliniq.com. After going through the details of your query, there are a few things to be clarified first. You have not mentioned any involvement of the small joints of hands, wrists or feet. The joints you have mentioned only include large joints. If it is really so, then the li...  Read Full »

Do you think that a skin test is enough to diagnose scleroderma?

Query: Hi doctor, I traveled to a different country to get more in depth testing of multiple health problems. I was diagnosed with the start of scleroderma, because of my gastrointestinal symptoms, idiopathic angioedema, thickened skin, weird blood vessels (tiny red tree-like veins), family history of scle...  Read Full »


Dr. Bharat Patodiya

Answer: Hi, Welcome to icliniq.com. Yes, in my opinion your case could be suggestive of scleroderma (autoimmune disorder - hardening of skin). However, I want to know the pattern of sclerosis. For scleroderma, it should start from hand and reach main trunk. Also, revert back with details of GI sympt...  Read Full »

I am pregnant. Do I need to protect the fetus from exposure to Methotrexate?

Query: Hello doctor, I am in my last trimester of pregnancy. My husband is currently undergoing chemotherapy for bone cancer. He was admitted to a hospital for a four-hour drip of Methotrexate. The hospital staff asked me to wear gloves before touching his body fluids or anything he has touched before that...  Read Full »


Dr. Uzma Arqam

Answer: Hello, Welcome to icliniq.com. I went through your query and understood your concern. Methotrexate is an anticancerous and immunosuppressive medicine. It is usually used in ectopic pregnancy, miscarriage, cancer, arthritis, etc. If a female has been using Methotrexate, it is advisable to conceive...  Read Full »

I got a PFT done. Kindly check and guide me if the values are fine.

Query: Hi doctor, I have a signal arthritis. Rib cage hurts when I breathe. I had a clear COPD four years back and normal PFT. I stopped smoking ten years ago. I am a swimmer and have breathing problem. I also have suspected connective tissue disease. I am currently taking Humira, Methotrexate and daily I ...  Read Full »


Dr. Divakara. P

Answer: Hi, Welcome to icliniq.com. Well, your pulmonary function test (PFT) values are totally fine. Any value above 80% of predicted value is considered as normal. So, your values are too good. For further information consult a pulmonologist online --> https://www.icliniq.com/ask-a-doctor-online/...  Read Full »

Is Prednicort a good medicine for arthritis pain?

Query: Hello doctor, I want an opinion for my mother. My mother has been feeling arthritis pain since last few years. Recently, I have read somewhere about a medicine name Prednicort (5 mg) which is specially used for asthma disease. But, I have read that this medicine is also helpful for arthritis pain. I...  Read Full »


Dr. Mahmoud Ahmed Abdelrahman Abouibrahim

Answer: Hello, Welcome to icliniq.com. Prednicort (Prednisolone) is a steroid which is good as an anti-inflammatory and painkiller in arthritis but has very serious adverse effects in the long term such as osteoporosis, gastritis, hypertension, and elevated blood sugar levels. Is she diagnosed with rheuma...  Read Full »

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