Can someone at 35 safely use CGRP injections long-term?

Question

Hello doctor,

I am 35 years old and experience migraines with aura about two to three times a month. They are usually triggered by stress and lack of sleep. I have tried triptans and magnesium supplements, but my neurologist is now recommending monthly CGRP injections.

My main concern is their long-term safety. Are there any known risks associated with using these injections for several years? Could they affect fertility or hormone levels?

Please help.

Answer 1

Hello,

Welcome to icliniq.com.

I have read your query and understand your concern.

CGRP (calcitonin gene-related peptide) monoclonal antibodies have become a very effective option for preventing migraines, especially when other treatments such as triptans or supplements have not provided sufficient relief.

Current evidence suggests that these medications are generally well tolerated, even with long-term use over several years, and no major safety concerns or serious side effects have been identified so far in ongoing studies.

For women of childbearing age, available data are also reassuring. At present, there is no strong evidence that CGRP blockers negatively affect fertility or hormone levels. So don't worry and get upset about it.

However, since these medications are relatively new compared to older migraine treatments, long-term research is continuing.

If you are planning a pregnancy or have concerns related to hormonal health, it is important to discuss this with your neurologist so that treatment timing and possible alternatives can be considered appropriately.

For many patients, CGRP blockers provide meaningful and consistent migraine prevention with a favorable overall safety profile, particularly when other preventive treatments have not been sufficiently effective.

I hope you are satisfied with my answer. For further queries, you can consult me at iCliniq.

Thank you.