I am 31. Will CGRP injections help control my migraines?

Question

Hello doctor,

I am a 31-year-old woman with chronic migraines that occur around ten to twelve days each month. I have tried Triptans and preventive medicines such as Propranolol, but the relief has been incomplete.

My neurologist suggested CGRP (calcitonin gene-related peptide receptor antagonist) inhibitor injections such as Erenumab.

Please tell me,

How effective are these in reducing migraine frequency?
Are the side effects serious?
Do patients usually need these injections lifelong, or can they eventually stop once symptoms improve?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

CGRP (calcitonin gene-related peptide) inhibitor injections, such as Erenumab (CGRP receptor antagonist biologic), represent a newer class of preventive therapy for patients with frequent or chronic migraines who have not responded well to conventional medications such as beta-blockers (beta-adrenergic blocking agent), antiepileptics (seizure preventers), or antidepressants (mood lifters).

These injections specifically target the CGRP pathway, which plays a central role in migraine development. They are generally considered safe and well-tolerated. The most common side effects include mild issues such as injection site reactions, constipation, muscle cramps, or fatigue, while serious adverse effects are rare.

An added advantage is convenience, since these injections are given once a month or once every few months, depending on the specific medication, compared to the need for daily tablets.

Regarding duration of use, many patients continue long-term treatment if their migraines return after stopping. However, some patients may be able to taper or discontinue therapy under medical supervision after achieving sustained improvement. Neurologists usually reassess treatment effectiveness after a few months and then decide whether ongoing therapy is necessary, tailoring the plan according to each patient’s response and long-term migraine control.

I hope this helps.

Thank you.