What are the potential risks of pregnancy with NMOSD?

Question

Hi doctor,

I am 30 years old and living with neuromyelitis optica spectrum disorder (NMOSD). My condition is currently stable, and I am considering getting pregnant.

What should I know about NMOSD treatment during pregnancy and potential risks to the baby?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

During pregnancy, neuromyelitis optica spectrum disorder (NMOSD) treatment options include continuation of Azathioprine, Eculizumab, or Tocilizumab, depending on disease severity before pregnancy. In cases of rituximab treatment, newborn B cell counts should be checked, and vaccination plans should be adjusted accordingly. Relapses during pregnancy can be managed with non-fluorinated glucocorticoids, plasma exchange, or immunoadsorption. Treatment of NMOSD during pregnancy may present risks to the newborn, particularly with the use of medications like Rituximab.

While the risk of miscarriage and congenital malformations is generally low, potential risks include:

Neonatal lymphopenia (reduced B cells), which can be reversible after six months.
A slight increase in the risk of infections.

I hope this information will help you.

Thanks.