Gene mutations that cause plasminogen activator inhibitor 1(PAI-1) deficiency are known as PAI mutations. PAI-1 is a body protein that is essential for normal clotting of the blood. PAI mutation leads to the deficiency of the PAI-1 protein. As a result, the person with the mutation has abnormal bleeding. It is a rare bleeding disorder in which an injury can lead to excessive and prolonged bleeding.
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