Q. Should I avoid folic acid during MTHFR pregnancy?

Answered by Dr. Sanjay Kumar Bhattacharyya and medically reviewed by iCliniq medical review team.

 

New
Do you have a question on Mthfr Mutation or Folic Acid? We have medical experts to help you right away. Ask a Doctor Now »
 

Hello doctor,

I am 5 weeks pregnant and I have MTHFR and PAI mutations. My doctor recommended me to take Folic acid. I read it should be avoided during MTHFR pregnancies. Along with that I am on Prozac and Euthyrox. What do you think? What should I do? Please help.


Related Questions:
How much Folic acid is required during pregnancy in Crohn's patient?
Is it advisable to have long flight travel during pregnancy?
In case of low-lying placenta, is it safe to fly?
 

Dr. Sanjay Kumar Bhattacharyya
MBBS., DCH., MD[OBSTETRICS & GYNECOLOGY
Obstetrics And Gynaecology

Hi,

Welcome to icliniq.com.

Truly speaking, MTHFR - methylene tetrahydrofolate reductase mutations are widely spread and all most one half of the population is having or carrying these mutations by different extent. By different extent, I mean to say, various levels of affection or involvement that is from very insignificant disease to severe disease.

I do want to know that in which category you are now. This is fairly judged by the serum levels of homocysteine, which is the protein that is increased in the blood. If you have a severe MTHFR defect, then you need to avoid Folic acid and also need to screen some fetal congenital defects like spina bifida or anencephaly at an earliest.

But, if you do not have any specific symptoms with this mutation, then there is no harm to take these vitamins. PAI mutations (plasminogen activator inhibitor) could result in abnormalities in blood clotting disorders. This actually poses no bar for taking Folic acid in pregnancy state.

For further information consult an obstetrician and gynaecologist online --> https://www.icliniq.com/ask-a-doctor-online/obstetrician-and-gynaecologist

 

Thank you doctor,

I have C677T heterozygous mutation and A1298C heterozygous mutation. I do not know what it means or how severe it is. I am asymptomatic and I just discovered it by chance a while ago.

 

Dr. Sanjay Kumar Bhattacharyya
MBBS., DCH., MD[OBSTETRICS & GYNECOLOGY
Obstetrics And Gynaecology

Hello,

Welcome back to icliniq.com.

Now, it is a bit clearer. There are different variations of MTHFR gene and among which C677T and A1298C are the commonest. If you were only heterozygous for any of them, then the matter could have been a bit subdued and your enzyme activity would be 60% of the normal. But, as you have both the genes in the heterozygous state, the problem might be there inside you and might be a bit complicated. You need an urgent consultation from an endocrinologist and a genetic specialist to assess your health status. You need screening for a few diseases right now.

For further information consult an obstetrician and gynaecologist online --> https://www.icliniq.com/ask-a-doctor-online/obstetrician-and-gynaecologist

 
 
Ask your health query to a doctor online?
 
Ask a Doctor Online »
* guaranteed answer within 4 hours.

Related Questions & Answers


Intermenstrual Bleeding or Spotting - Is it Normal or Should I be Worried?
Article Overview: Intermenstrual vaginal bleeding or spotting or bleeding between periods is considered abnormal and may usually require a patient seeing a doctor. It is also termed metrorrhagia. Normally, a woman has a regular menstrual cycle of 28 days with ranges between 21-35 days considered normal and menses can last for 2-7 days. Any bleeding out of these are considered abnormal.  Read Article »
Dr. Nsah Bernard
Obstetrician And Gynaecologist

Causes of Intermenstrual bleeding: Intermenstrual bleeding or bleeding between periods can be caused by a vast number of factors which may be physical or organic and psychosocial. If you are experiencing intermenstrual bleeding, then your doctor maybe a able to rule out one of the below most probab ...  Read Article »
 
Ectopic Pregnancy
Article Overview: In an ectopic pregnancy, the fertilized egg gets attached anywhere outside the uterus. Ectopic pregnancies are very common and occur in about 1 in every 50 pregnancies. It is a medical emergency and if left untreated, can also be fatal.  Read Article »
Dr. K Sneha
Obstetrician And Gynaecologist

What is an Ectopic Pregnancy? Fertilization of the ovum by sperm takes place in the fallopian tubes. After fertilization, the fertilized egg travels through the fallopian tube to the uterus. Normally, this embryo gets attached to the wall of the uterus and develops. In an ectopic pregnancy, the fer ...  Read Article »
 
 

Ask your health query to a doctor online?
 
Ask a Doctor Online »
* guaranteed answer within 4 hours.
 

Ask a Doctor Online

* guaranteed answer within 4 hours
 

Most Viewed


Ankylosing Spondylitis
This article discusses about the causes, pathology, clinical features, musculoskeletal manifestation, investigation and ...Read more »
Is having severe leg pain during pregnancy normal?
Hello doctor, There is a complaint of severe pain in both the legs in my wife who is 14 weeks pregnant. She is unable t ...Read more »
The pulse rate started to fall after giving Epinephrine in a 4-year-old child. Kindly give your opinion.
Hello doctor, I am reviewing the patient care of a 4-year-old child diagnosed with the flu. He was having trouble breat ...Read more »