Does compounded Semaglutide work differently than Wegovy?

Question

Hello doctor,

I am a 40-year-old female with polycystic ovary syndrome (PCOS) and obesity. I started using compounded Semaglutide two months ago for weight loss, but I have noticed that the appetite suppression is not as strong as expected, and I am experiencing more nausea compared to when I used other formulations like Wegovy.

Could variations in the compounding process be affecting the drug’s effectiveness and side effects? Should I discuss a dosage adjustment or switch to a different formulation with my doctor? Please help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

I read your query and can understand your concern.

Based on your medical history and concerns regarding semaglutide treatment, I would like to provide you with a detailed explanation of Semaglutide, its mechanism of action, benefits, and possible side effects.

Semaglutide overview:

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which mimics the function of the body’s natural GLP-1 hormone.
It plays a vital role in regulating blood sugar levels by stimulating insulin production and suppressing glucagon (a hormone that raises blood sugar levels).
Semaglutide works by imitating the effects of the GLP-1 hormone, helping to improve glucose control.
It also prevents the liver from producing excess glucose, which helps maintain balanced blood sugar levels.

Benefits of Semaglutide:

Blood sugar control – Studies have shown that semaglutide can effectively lower blood sugar levels in adults with type 2 diabetes.
Weight loss – It has also been associated with weight loss, providing an additional benefit for individuals with type 2 diabetes who are overweight or obese.

Possible side effects:

Gastrointestinal issues, including nausea, vomiting, diarrhea, and abdominal pain.

It is important not to take semaglutide based on the advice of a random pharmacy or without consulting a doctor.

Addressing your concern:

Since you mentioned that you are on Semaglutide and experiencing increased nausea as a side effect, changing the brand or formulation may not always help in reducing nausea, vomiting, or other side effects.

However, a dosage adjustment may help in minimizing these effects. I recommend following up with your doctor to discuss whether an adjustment is needed.

I hope this helps.

Kindly revert so I can assist you further.

Thank you.