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What are the side effects of using compounded Semaglutide?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I have been using compounded Semaglutide for weight management, but over the past few weeks, I have developed tingling sensations, neuropathic pain, and muscle weakness. My doctor thinks it might be an immune-mediated reaction to impurities in the compounded formulation. How common is this kind of side effect compared to the FDA-approved version? Should I stop the medication immediately, and what tests might help determine the cause? I’m really concerned about possible long-term nerve damage.

Please help me.

Thanks.

Answered by Dr. Srinivasa Murthy

Education:

MBBS

Professional Bio:

Dr. Srinivasa, with extensive 17 experience in diabetes reversal, weight management, and hormone-related conditions, takes a holistic, patient-centric approach. He specializes in lifestyle modifications and personalized nutrition, using evidence-based medicine to treat diseases at their root. His methods help patients achieve lasting health while reducing or eliminating medications.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

I can understand your concern.

Compounded Semaglutide can sometimes cause side effects due to impurities, which are less common with FDA-approved versions. Tingling sensations, neuropathic pain, and muscle weakness may indicate an adverse reaction. It is advisable to stop the medication immediately and consult your doctor. Diagnostic tests such as blood tests, nerve conduction studies, and electromyography can help determine the cause. Addressing this promptly can prevent long-term nerve damage.

Feel free to follow up with any further questions or concerns.

Thank you.

Medically reviewed by iCliniq medical review team
Published At June 7, 2025
Reviewed At June 9, 2025

Education:

MBBS

Professional Bio:

Dr. Srinivasa, with extensive 17 experience in diabetes reversal, weight management, and hormone-related conditions, takes a holistic, patient-centric approach. He specializes in lifestyle modifications and personalized nutrition, using evidence-based medicine to treat diseases at their root. His methods help patients achieve lasting health while reducing or eliminating medications.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Srinivasa, with extensive 17 experience in diabetes reversal, weight management, and hormone-related conditions, takes a holistic, patient-centric approach. He specializes in lifestyle modifications and personalized nutrition, using evidence-based medicine to treat diseases at their root. His methods help patients achieve lasting health while reducing or eliminating medications.

This doctor is not available for online consultations on the platform anymore.

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