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Are vitamin supplements effective for tardive dyskinesia?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am a 36-year-old female with bipolar disorder. After years of taking antipsychotic medications, I developed tardive dyskinesia, which includes symptoms like lip smacking, blinking, and tongue movements. This has become quite embarrassing for me socially. My psychiatrist has already reduced my medication dose.

I keep reading that vitamin B6 and vitamin E supplements may help with tardive dyskinesia. Should I, as a 36-year-old with this condition, consider trying these supplements? I also take lithium and thyroid medication, so I am concerned about potential interactions or side effects from taking high doses of vitamins. Are there any proven benefits of these supplements for tardive dyskinesia, or is it mainly anecdotal evidence from people experimenting with different remedies?

Please guide.

Hello,

Welcome to icliniq.com.

I understand your concern.

Please share your current treatment and past treatment records with me. There are different treatment strategies available for tardive dyskinesia, and the best option will depend on your current medications, how long you have been on antipsychotics, and the dosage and type of antipsychotic being used.

High-dose vitamin E can range from 400 to 1600 mg per day, taken in divided doses. Additionally, vitamin B6 is an evidence-based treatment that can help reduce tremors. Both of these are antioxidants, so their interactions with psychotropic medications are minimal.

The FDA has approved Tetrabenazine and Valbenazine for the treatment of tardive dyskinesia, both of which have shown good response rates in the market. Clonazepam and Amantadine are also effective, evidence-based treatment options available for individuals with tardive dyskinesia.

Please respond with your treatment records. This information is helpful to you.

Take care.

Medically reviewed byiCliniq medical review team

Published At May 17, 2026
Reviewed AtMay 18, 2026

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