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Can Tezspire worsen asthma symptoms?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I started Tezspire (Tezepelumab) two months ago for my eosinophilic asthma, but lately I have been experiencing increased chest tightness and sinus issues. I hoped it would help reduce flare-ups, but my breathing seems worse now.

Is there typically a delay before Tezspire begins to show benefits? Could I be having an allergic reaction to this biologic? Should I consider stopping it or combining it with another treatment? Please help.

Thank you.

Hi,

Welcome to icliniq.com.

I read your query and can understand your concern.

Tezspire (Tezepelumab) is a biologic medication approved for the treatment of severe asthma, particularly in patients with eosinophilic or uncontrolled asthma. It has an average rating of 8.7 out of 10, based on a total of 32 reviews for the treatment of asthma. Among these reviewers, 84 % reported a positive experience, while 3 % reported a negative experience.

Common side effects of Tezspire:

  1. Back pain.

  2. Skin rash.

  3. Sore throat.

  4. Injection site reactions.

  5. Joint pain (arthralgia) - reported in 1 % to 10 % of users.

  6. Breathing difficulties.

  7. Fever.

  8. Red, itchy, swollen, or inflamed eyes.

These side effects are usually temporary and may last from a few days to a few weeks. However, if side effects persist, worsen, or become bothersome, it is essential to consult your doctor or pharmacist.

I hope this helps.

Kindly revert so I can assist you further.

Thank you.

The Probable causes

Asthma.

Probable diagnosis

Moderate to severe asthma (possibly eosinophilic asthma).

Treatment plan

Initiate or continue treatment with Tezspire under the supervision of a healthcare provider. Additional medications or therapies may be considered based on response.

Medically reviewed byiCliniq medical review team

Published At June 22, 2025
Reviewed AtJune 24, 2025

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